Gentile Pietro, Scioli Maria Giovanna, Bielli Alessandra, Orlandi Augusto, Cervelli Valerio
Plastic & Reconstructive Surgery, Department of Biomedicine & Prevention, University of Rome 'Tor Vergata', Rome, Italy.
Department of Biomedicine & Prevention, Anatomic Pathology Institute, University of Rome 'Tor Vergata', Rome, Italy.
Regen Med. 2017 Dec;12(8):939-952. doi: 10.2217/rme-2017-0076. Epub 2017 Dec 13.
Recently, a new fat grafting technique termed 'nanofat grafting' was proposed which improved tissue repair by the stem cells contained in the stromal vascular fraction (SVF) of nanofat. Here, we reported the clinical outcomes of different nanofat procedures in the treatment of scars in relation with SVF cell yield.
Three different modified nanofat grafting procedures (supercharged-, evo- and centrifuged-modified nanofat) were compared with the classic nanofat method, and histological analysis was performed to assess skin regeneration. Residual nanofat samples were analyzed to determine SVF immunophenotype and yield from each procedure.
Supercharged-modified nanofat gave the best results in terms of clinical outcome and SVF yield. Histological analysis revealed similar skin regeneration in all treatments.
This work suggested a positive correlation between SVF yield and clinical outcomes in the nanofat treatment of scars.
最近，一种名为“纳米脂肪移植”的新型脂肪移植技术被提出，该技术通过纳米脂肪的基质血管成分（SVF）中所含的干细胞改善组织修复。在此，我们报告了不同纳米脂肪手术治疗瘢痕的临床结果及其与SVF细胞产量的关系。
将三种不同改良的纳米脂肪移植手术（增压改良纳米脂肪、进化改良纳米脂肪和离心改良纳米脂肪）与经典纳米脂肪方法进行比较，并进行组织学分析以评估皮肤再生情况。对剩余的纳米脂肪样本进行分析，以确定每种手术的SVF免疫表型和产量。
增压改良纳米脂肪在临床结果和SVF产量方面取得了最佳效果。组织学分析显示，所有治疗方法的皮肤再生情况相似。
这项研究表明，在纳米脂肪治疗瘢痕中，SVF产量与临床结果之间存在正相关。
