Honda Tetsuya, Kabashima Kenji
Department of Dermatology, Kyoto University Graduate School of Medicine.
Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(5):337-343. doi: 10.2177/jsci.40.337.
Skin is an outermost organ that serves as an interface between the host and the environment. The skin provides not only mechanical barrier functions, but also an active immunological barrier that provides the first line of defense against infections. For the effective clearance of pathogens or antigens in the skin, immune cells, especially effector T cells, must quickly exert their effector functions while avoiding the host damage by their excess activation. Therefore, the quality, magnitude, and the duration of the effector T cell activity must be carefully regulated. Here, we will review our recent findings on the effector T cell dynamics, dendritic cell dynamics, and the regulatory mechanisms for effector T cells activation in the skin, as revealed by the live imaging techniques using multi-photon microscopy.
皮肤是最外层的器官，作为宿主与环境之间的界面。皮肤不仅提供机械屏障功能，还提供主动免疫屏障，构成抵御感染的第一道防线。为了有效清除皮肤中的病原体或抗原，免疫细胞，尤其是效应T细胞，必须迅速发挥其效应功能，同时避免因过度激活而对宿主造成损伤。因此，效应T细胞活性的质量、强度和持续时间必须得到严格调控。在这里，我们将回顾我们最近的研究发现，这些发现是通过使用多光子显微镜的实时成像技术揭示的，涉及皮肤中效应T细胞动力学、树突状细胞动力学以及效应T细胞激活的调控机制。
