Pickering W J, Birch D F
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia.
Infect Immun. 1989 Apr;57(4):1235-9. doi: 10.1128/iai.57.4.1235-1239.1989.
A challenge procedure based on reflux of Ureaplasma urealyticum to the rat kidney was used to examine the disease-causing potential of this species for the upper urinary tract. Renal infection was detected 8 days after challenge in 90 to 100% of animals exposed to 10(7) ureaplasmas but was not detected in animals exposed to fewer than 10(6) microorganisms. Viable microorganisms were recoverable from more than 60% of infected animals throughout a 24-week follow-up period of study. Animals with persistent infection exhibited a humoral response involving immunoglobulin M and immunoglobulin G antibody. These results show that U. urealyticum is capable of giving rise to chronic infection in the kidneys of rats following challenge via the ascending route.
采用基于解脲脲原体反流至大鼠肾脏的激发程序，来检测该菌种对上泌尿道的致病潜力。在接受10⁷ 解脲脲原体的动物中，90%至100%在激发后8天检测到肾脏感染，但在接受少于10⁶ 微生物的动物中未检测到感染。在整个为期24周的研究随访期内，超过60%的感染动物可分离出活的微生物。持续感染的动物表现出涉及免疫球蛋白M和免疫球蛋白G抗体的体液反应。这些结果表明，解脲脲原体通过上行途径激发后能够在大鼠肾脏中引起慢性感染。
