Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
Division of Rheumatology, Allergy, and Immunology, Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Rheumatology (Oxford). 2018 May 1;57(suppl_4):iv34-iv42. doi: 10.1093/rheumatology/kex417.
OA is a multifaceted and heterogeneous syndrome that may be amenable to tailored treatment. There has been an increasing focus within the OA research community on the identification of meaningful OA phenotypes with potential implications for prognosis and treatment. Experimental and clinical data combined with sophisticated statistical approaches have been used to characterize and define phenotypes from the symptomatic and structural perspectives. An improved understanding of the existing phenotypes based on underlying disease mechanisms may shed light on the distinct entities that make up the disease. This narrative review provides an updated summary of the most recent advances in this field as well as limitations from previous approaches that can be addressed in future studies.
OA 是一种多方面且异质性的综合征，可能适合进行针对性治疗。OA 研究界越来越关注从有意义的 OA 表型进行识别，这些表型可能对预后和治疗有潜在影响。实验和临床数据结合复杂的统计方法，已被用于从症状和结构角度来描述和定义表型。基于潜在疾病机制对现有表型的深入了解，可能揭示组成该疾病的不同实体。本综述性文章提供了该领域最新进展的最新总结，以及以前方法的局限性，这些局限性可以在未来的研究中得到解决。
