异常β波功率是功能性运动障碍中明确运动控制的标志。
Abnormal beta power is a hallmark of explicit movement control in functional movement disorders.
机构信息
From St. George's (T.T., G.N., M.J.E.), University of London, and St. George's University Hospitals NHS Foundation Trust, London, UK; Instituto de Medicina Molecular (T.T.), Faculdade de Medicina, Universidade de Lisboa & Serviço de Neurologia, Hospital de Santa Maria, Portugal; Department of Neurology (A.M.M.), University Medical Center Groningen and University of Groningen, the Netherlands; Sobell Department of Motor Neuroscience and Movement Disorders (S.L., A.M.), University College of London, Institute of Neurology; Faculty of Health, Social Care and Education (R.G.), Kingston University and St. George's, University of London, UK; and Neurology Department (I.P.), Hospital Ruber Internacional, Madrid, Spain.
出版信息
Neurology. 2018 Jan 16;90(3):e247-e253. doi: 10.1212/WNL.0000000000004830. Epub 2017 Dec 22.
OBJECTIVE
To determine whether sensorimotor beta-frequency oscillatory power is raised during motor preparation in patients with functional movement disorders (FMD) and could therefore be a marker of abnormal "body-focused" attention.
METHODS
We analyzed motor performance and beta-frequency cortical oscillations during a precued choice reaction time (RT) task with varying cue validity (50% or 95% congruence between preparation and go cues). We compared 21 patients with FMD with 13 healthy controls (HCs).
RESULTS
In HCs, highly predictive cues were associated with faster RT and beta desynchronization in the contralateral hemisphere (contralateral slope -0.045 [95% confidence interval (CI) -0.057 to -0.033] vs ipsilateral -0.033 [95% CI -0.046 to -0.021], < 0.001) and with a tendency for reaching lower contralateral end-of-preparation beta power (contralateral -0.482 [95% CI -0.827 to -0.137] vs ipsilateral -0.328 [95% CI -0.673 to 0.016], = 0.069). In contrast, patients with FMD had no improvement in RTs with highly predictive cues and showed an impairment of beta desynchronization and lateralization before movement.
CONCLUSIONS
Persistent beta synchronization during motor preparation could reflect abnormal explicit control of movement in FMD. Excessive attention to movement itself rather than the goal might maintain beta synchronization and impair performance.
目的
确定感觉运动β频带振荡功率是否在功能性运动障碍（FMD）患者的运动准备期间升高，因此是否可以作为异常“身体聚焦”注意力的标志物。
方法
我们分析了运动表现和β频带皮质振荡，在具有不同线索有效性（准备和GO 线索之间的一致性为 50%或 95%）的预提示选择反应时间（RT）任务中。我们将 21 名 FMD 患者与 13 名健康对照（HC）进行了比较。
结果
在 HC 中，高度预测性线索与更快的 RT 和对侧半球的β去同步化相关（对侧斜率-0.045[95%置信区间（CI）-0.057 至-0.033]与同侧-0.033[95%CI-0.046 至-0.021]，<0.001），并且达到较低的对侧准备结束β功率的趋势（对侧-0.482[95%CI-0.827 至-0.137]与同侧-0.328[95%CI-0.673 至 0.016]，=0.069）。相比之下，FMD 患者在高度预测性线索下的 RT 没有改善，并且在运动前表现出β去同步化和侧化的损害。
结论
运动准备期间持续的β同步可能反映了 FMD 中运动的异常显性控制。对运动本身的过度关注而不是目标可能会维持β同步并损害表现。
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