Barnosky Adrienne, Kroeger Cynthia M, Trepanowski John F, Klempel Monica C, Bhutani Surabhi, Hoddy Kristin K, Gabel Kelsey, Shapses Sue A, Varady Krista A
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Endocrinology, Diabetes and Metabolism, Wheaton Franciscan Healthcare, Ascension, Wauwatosa, WI, USA.
Nutr Healthy Aging. 2017 Dec 7;4(3):255-263. doi: 10.3233/NHA-170031.
Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown.
This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone metabolism in a 6-month randomized controlled trial.
Overweight and obese subjects ( = 100) were randomized to 1 of 3 groups for 6 months: 1) ADF (25% energy intake fast day, alternated with 125% intake feast day; 2) CR (75% intake every day); or 3) control (usual intake every day).
Body weight decreased similarly ( < 0.001) by ADF (-7.8±1.2%) and CR (-8.8±1.5%), relative to controls by month 6. Lean mass, total body bone mineral content and total body bone mineral density remained unchanged in all groups. Circulating osteocalcin, bone alkaline phosphatase, and C-terminal telopeptide type I collagen (CTX) did not change in any group. IGF-1 increased ( < 0.01) in the CR group, with no change in the ADF or control group. When the data were sub-analyzed according to menopausal status, there were no differences between premenopausal or postmenopausal women for any marker of bone metabolism.
These findings suggest that 6 months of ADF does not have any deleterious impact on markers of bone metabolism in obese adults with moderate weight loss.
隔日禁食（ADF）是一种新型饮食疗法，可减轻体重，但其对骨骼健康的影响尚不清楚。
本研究在一项为期6个月的随机对照试验中，考察了ADF与传统每日热量限制（CR）对骨代谢标志物的影响。
超重和肥胖受试者（n = 100）被随机分为3组，每组6个月：1）ADF组（禁食日能量摄入为25%，与进食日125%的摄入量交替进行）；2）CR组（每天摄入量为75%）；或3）对照组（每天正常摄入量）。
到第6个月时，相对于对照组，ADF组（-7.8±1.2%）和CR组（-8.8±1.5%）的体重下降程度相似（P<0.001）。所有组的瘦体重、全身骨矿物质含量和全身骨矿物质密度均保持不变。所有组的循环骨钙素、骨碱性磷酸酶和I型胶原C端肽（CTX）均未发生变化。CR组的胰岛素样生长因子-1（IGF-1）升高（P<0.01），ADF组和对照组无变化。根据绝经状态对数据进行亚分析时，绝经前或绝经后女性的任何骨代谢标志物均无差异。
这些发现表明，6个月的ADF对中度体重减轻的肥胖成年人的骨代谢标志物没有任何有害影响。
