a The Department of Internal Medicine , Konya Health Application and Research Center, University of Health Sciences , Konya , Turkey.
b The Division of Nephrology and Internal Medicine , Konya Health Application and Research Center, University of Health Sciences , Konya , Turkey.
Ren Fail. 2018 Nov;40(1):1-7. doi: 10.1080/0886022X.2017.1419962.
The risks of sudden death and cardiac arrhythmia are increased in patients with chronic kidney disease (CKD). Here, we aimed to evaluate the indicators of arrhythmias, such as p-wave dispersion (P-WD), QTc dispersion, Tp-e and Tp-e/QT ratio in patients with CKD stages 3-5 on no renal replacement therapy (RRT).
One-hundred and thirty three patients with CKD stages 3-5 and 32 healthy controls were enrolled into the study. No patients received RRT. QTc dispersion, P-WD and Tp-e interval were measured using electrocardiogram and Tp-e/QT ratio was also calculated.
Mean age rates were found similar in patients and controls (60.8 ± 14.2 and 61 ± 12.9 y, p = .937, respectively). Compared patients with controls, P-WD (45.85 ± 12.42 vs. 21.17 ± 6.6 msec, p < .001), QTc-min (366.99 ± 42.31 vs. 387.15 ± 20.5 msec, p < .001), QTc dispersion (71.13 ± 27.95 vs. 41.25 ± 14.55 msec, p < .001), Tp-e maximum (81.04 ± 10.34 vs. 75.49 ± 10.9 msec, p < .001), Tp-e minimum (62.25 ± 7.58 vs. 54.8 ± 6.72 msec, p < .001) and Tp-e/QTc ratio (0.19 ± 0.02 vs. 0.18 ± 0.01, p = .001) were found to be different. QTc-max and Tp-e interval were found to be similar in both groups.
P-WD and QTc dispersion, Tp-e interval and Tp-e/QTc ratio were found to be increased in with CKD stages 3-5 on no RRT.
患有慢性肾脏病（CKD）的患者猝死和心律失常的风险增加。在这里，我们旨在评估心律失常的指标，如未接受肾脏替代治疗（RRT）的 CKD 3-5 期患者的 P 波离散度（P-WD）、QTc 离散度、Tp-e 和 Tp-e/QT 比值。
将 133 名 CKD 3-5 期患者和 32 名健康对照者纳入研究。没有患者接受 RRT。使用心电图测量 QTc 离散度、P-WD 和 Tp-e 间期，并计算 Tp-e/QT 比值。
患者和对照组的平均年龄相似（60.8±14.2 和 61±12.9 岁，p=0.937）。与对照组相比，P-WD（45.85±12.42 对 21.17±6.6 msec，p<0.001）、QTc-min（366.99±42.31 对 387.15±20.5 msec，p<0.001）、QTc 离散度（71.13±27.95 对 41.25±14.55 msec，p<0.001）、Tp-e 最大（81.04±10.34 对 75.49±10.9 msec，p<0.001）、Tp-e 最小（62.25±7.58 对 54.8±6.72 msec，p<0.001）和 Tp-e/QTc 比值（0.19±0.02 对 0.18±0.01，p=0.001）不同。两组 QTc-max 和 Tp-e 间期相似。
在未接受 RRT 的 CKD 3-5 期患者中，发现 P-WD 和 QTc 离散度、Tp-e 间期和 Tp-e/QTc 比值增加。
