从块茎中分离得到的新型葫芦烷三萜及其细胞毒性。
Novel Cucurbitane Triterpenes from the Tubers of with Their Cytotoxic Acitivity.
机构信息
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China.
出版信息
Molecules. 2019 Jan 17;24(2):331. doi: 10.3390/molecules24020331.
Chemical research of the medicinal plant (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A⁻E (⁻) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds ⁻ were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC ranging from 5.9 to 33.9 μM compared to Cisplatin.
药用植物（葫芦科）的化学研究通过硅胶柱、ODS 柱和半高效液相色谱技术得到了五个新的葫芦烷型三萜化合物 hemslelis A⁻E（⁻）。通过光谱分析确定了它们的结构，并与之前研究中的现有数据进行了比较。化合物 ⁻ 对三种人肿瘤细胞系 Hela、HCT-8 和 HepG-2 的细胞毒性活性进行了评估，其 IC 范围为 5.9 至 33.9 μM，与顺铂相比。
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