Soustek Z
Department of Pathology KUNZ-Pilsen, Dobrany, Czechoslovakia.
Zentralbl Allg Pathol. 1989;135(1):25-32.
The autopsy was performed in 225 cases of chronic schizophrenia. In 44 cases examination of the brain by light microscope revealed changes typical of Alzheimer's disease. The increased risk for the development of Alzheimer's disease in chronic schizophrenia is pointed out. In 8 schizophrenics where death occurred suddenly and unexpectedly electronmicroscopy of brain was carried out. Clusters of a great number of synaptic vesicles were found in presynaptic knobs in the brain cortex of the schizophrenics but not in the controls; the postmortal origin and/or fixation artefact origin of the clusters were excluded. The possible "immunologic dependent" clustering of synaptic vesicles is discussed. The new "modul concept" in the structure of the brain cortex is used to make the role of synapses in the mental process more clear.
对225例慢性精神分裂症患者进行了尸检。在44例患者中，通过光学显微镜检查大脑发现了阿尔茨海默病的典型变化。指出了慢性精神分裂症患者患阿尔茨海默病风险增加的情况。对8例突然意外死亡的精神分裂症患者进行了脑电镜检查。在精神分裂症患者大脑皮层的突触前终扣中发现了大量突触小泡簇，而对照组中未发现；排除了这些簇的死后形成和/或固定假象形成。讨论了突触小泡可能的“免疫依赖性”聚集。运用大脑皮层结构中的新“调节概念”来更清楚地阐明突触在心理过程中的作用。
