Unité de virologie, Centre National de Référence-Laboratoire Expert Orthopoxvirus, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
Viruses. 2017 Dec 23;10(1):3. doi: 10.3390/v10010003.
Since the official declaration of smallpox eradication in 1980, the general population vaccination has ceased worldwide. Therefore, people under 40 year old are generally not vaccinated against smallpox and have no cross protection against orthopoxvirus infections. This naïve population may be exposed to natural or intentional orthopoxvirus emergences. The virology unit of the Institut de Recherche Biomédicale des Armées (France) has developed research programs on orthopoxviruses since 2000. Its missions were conceived to improve the diagnosis capabilities, to foster vaccine development, and to develop antivirals targeting specific viral proteins. The role of the virology unit was asserted in 2012 when the responsibility of the National Reference Center for the Orthopoxviruses was given to the unit. This article presents the evolution of the unit activity since 2000, and the past and current research focusing on orthopoxviruses.
自 1980 年宣布消灭天花以来，全球范围内已停止对普通人群进行天花疫苗接种。因此，40 岁以下的人群通常未接种过天花疫苗，对正痘病毒感染也没有交叉保护作用。这群无免疫力的人群可能会接触到自然或人为的正痘病毒暴发。自 2000 年以来，法国军队生物医学研究所（Institut de Recherche Biomédicale des Armées，IRBA）的病毒学部门开展了正痘病毒的研究计划。其任务旨在提高诊断能力，促进疫苗的开发，并针对特定的病毒蛋白开发抗病毒药物。2012 年，该病毒学部门被赋予国家正痘病毒参考中心的责任，这彰显了其作用。本文介绍了自 2000 年以来该部门活动的演变，以及过去和当前专注于正痘病毒的研究。
