Altenburg A, Zouboulis C C
Department of Dermatology, Dessau Medical Center, Dessau, Germany.
Skin Therapy Lett. 2008 Sep;13(7):1-4.
The treatment of recurrent aphthous stomatitis (RAS) still remains nonspecific and is based primarily on empirical data. The goals of therapy include the management of pain and functional impairment by suppressing inflammatory responses, as well as reducing the frequency of recurrences or avoiding the onset of new aphthae. For common forms of RAS, standard topical treatment options that provide symptomatic relief include analgesics, anesthetics, antiseptics, anti-inflammatory agents, steroids, sucralfate, tetracycline suspension, and silver nitrate. Dietary modifications may also support therapeutic measures. In resistant cases of benign aphthosis or aphthosis with systemic involvement, appropriate systemic treatment can be selected from a wide spectrum of immunomodulators that include colchicine, prednisolone, cyclosporine A, interferon-a, tumor necrosis factor-a antagonists, antimetabolites, and alkylating agents.
复发性阿弗他口炎（RAS）的治疗仍然缺乏特异性，主要基于经验数据。治疗目标包括通过抑制炎症反应来管理疼痛和功能障碍，以及减少复发频率或避免新口疮的发作。对于常见形式的RAS，提供症状缓解的标准局部治疗选择包括镇痛药、麻醉剂、防腐剂、抗炎药、类固醇、硫糖铝、四环素混悬液和硝酸银。饮食调整也可能有助于治疗措施。在良性口疮或伴有全身受累的口疮的耐药病例中，可以从多种免疫调节剂中选择适当的全身治疗方法，这些免疫调节剂包括秋水仙碱、泼尼松龙、环孢素A、干扰素-α、肿瘤坏死因子-α拮抗剂、抗代谢物和烷化剂。
