Kobayashi F, Sagawa N, Nakamura K, Nonogaki M, Ban C, Fujii S, Mori T
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
Am J Obstet Gynecol. 1989 Mar;160(3):563-6. doi: 10.1016/s0002-9378(89)80027-4.
To clarify the mechanism of CA 125 elevation in maternal sera, serum levels of CA 125 and CA 19-9 were measured in 122 apparently healthy pregnant women (fifth to fortieth week of gestation) and 50 postpartum women (26 term deliveries and 24 second-trimester induced abortions). Serum levels of CA 125 showed an initial increase by the tenth week and then decreased to less than 35 U/ml, remaining below this level until delivery. However, within 1 hour after term delivery or second-trimester induced abortion, the CA 125 levels showed a second increase and decreased rapidly thereafter. In contrast, serum levels of CA 19-9 did not change significantly during these periods. Combined with our previous finding that the decidua contains abundant CA 125 but little CA 19-9, these results indicate that the elevated CA 125 levels in maternal sera originate from the decidual cells affected by chorionic invasion or the placental separation.
为阐明孕妇血清中CA 125升高的机制，对122名明显健康的孕妇（妊娠第5至40周）和50名产后妇女（26例足月分娩和24例中期引产）测定了血清CA 125和CA 19-9水平。血清CA 125水平在妊娠第10周时开始升高，然后降至低于35 U/ml，并在分娩前一直维持在该水平以下。然而，在足月分娩或中期引产术后1小时内，CA 125水平出现第二次升高，随后迅速下降。相比之下，CA 19-9血清水平在这些时期无明显变化。结合我们之前的发现，即蜕膜含有丰富的CA 125但几乎不含CA 19-9，这些结果表明孕妇血清中升高的CA 125水平源自受绒毛膜侵袭或胎盘分离影响的蜕膜细胞。
