维生素D与ω-3脂肪酸联合补充对妊娠期糖尿病患者炎症、氧化应激生物标志物及妊娠结局的影响
The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes.
作者信息
Razavi Maryamalsadat, Jamilian Mehri, Samimi Mansooreh, Afshar Ebrahimi Faraneh, Taghizadeh Mohsen, Bekhradi Reza, Seyed Hosseini Elahe, Haddad Kashani Hamed, Karamali Maryam, Asemi Zatollah
机构信息
Department of Gynecology and Obstetrics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
出版信息
Nutr Metab (Lond). 2017 Dec 28;14:80. doi: 10.1186/s12986-017-0236-9. eCollection 2017.
BACKGROUND
This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM) patients.
METHODS
This randomized, double-blind, placebo-controlled trial was conducted among 120 GDM women. Participants were randomly divided into four groups to receive: 1) 1000 mg omega-3 fatty acids containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo ( = 30); 2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 30); 3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 30) and 4) vitamin D placebo + omega-3 fatty acids placebo (n = 30) for 6 weeks.
RESULTS
Subjects who received vitamin D plus omega-3 fatty acids supplements compared with vitamin D, omega-3 fatty acids and placebo had significantly decreased high-sensitivity C-reactive protein (-2.0 ± 3.3 vs. -0.8 ± 4.4, -1.3 ± 2.4 and +0.9 ± 2.7 mg/L, respectively, = 0.008), malondialdehyde (-0.5 ± 0.5 vs. -0.2 ± 0.5, -0.3 ± 0.9 and +0.5 ± 1.4 μmol/L, respectively, < 0.001), and increased total antioxidant capacity (+92.1 ± 70.1 vs. +55.1 ± 123.6, +88.4 ± 95.2 and +1.0 ± 90.8 mmol/L, respectively, = 0.001) and glutathione (+95.7 ± 86.7 vs. +23.0 ± 62.3, +30.0 ± 66.5 and -7.8 ± 126.5 μmol/L, respectively, P = 0.001). In addition, vitamin D and omega-3 fatty acids co-supplementation, compared with vitamin D, omega-3 fatty acids and placebo, resulted in lower incidences of newborns' hyperbilirubinemiain ( = 0.037) and newborns' hospitalization ( = 0.037).
CONCLUSION
Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM women had beneficial effects on some biomarkers of inflammation, oxidative stress and pregnancy outcomes.
背景
本研究旨在确定联合补充维生素D和ω-3脂肪酸对妊娠期糖尿病（GDM）患者炎症、氧化应激生物标志物及妊娠结局的影响。
方法
本随机、双盲、安慰剂对照试验在120名GDM女性中进行。参与者被随机分为四组，分别接受：1）每天两次服用含180毫克二十碳五烯酸（EPA）和120毫克二十二碳六烯酸（DHA）的1000毫克ω-3脂肪酸 + 维生素D安慰剂（n = 30）；2）每2周服用50000国际单位维生素D + ω-3脂肪酸安慰剂（n = 30）；3）每2周服用50000国际单位维生素D + 每天两次服用1000毫克ω-3脂肪酸（n = 30）；4）维生素D安慰剂 + ω-3脂肪酸安慰剂（n = 30），为期6周。
结果
与单独服用维生素D、ω-3脂肪酸及安慰剂相比，联合补充维生素D和ω-3脂肪酸的受试者高敏C反应蛋白显著降低（分别为-2.0±3.3 vs. -0.8±4.4、-1.3±2.4和+0.9±2.7毫克/升，P = 0.008），丙二醛显著降低（分别为-0.5±0.5 vs. -0.2±0.5、-0.3±0.9和+0.5±1.4微摩尔/升，P < 0.001），总抗氧化能力显著升高（分别为+92.1±70.1 vs. +55.1±123.6、+88.4±95.2和+1.0±90.8毫摩尔/升，P = 0.001），谷胱甘肽显著升高（分别为+95.7±86.7 vs. +23.0±62.3、+30.0±66.5和-7.8±126.5微摩尔/升，P = 0.001）。此外，与维生素D、ω-3脂肪酸及安慰剂相比，联合补充维生素D和ω-3脂肪酸可降低新生儿高胆红素血症（P = 0.037）和新生儿住院率（P = 0.037）。
结论
总体而言，GDM女性联合补充维生素D和ω-3脂肪酸6周对炎症、氧化应激的一些生物标志物及妊娠结局具有有益影响。
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