SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma.

There is increasing evidence for the contribution of synuclein alpha () to the etiology of neurological disorders, such as Parkinson's disease (PD). However, little is known about the detailed role of in human cancers, especially lung cancers. Here, we evaluated the effects of on the occurrence and prognosis of lung adenocarcinoma (ADC). Comprehensive bioinformatics analyses of data obtained from the Oncomine platform, the human protein atlas (HPA) project and the cancer cell line encyclopedia (CCLE) demonstrated that expression was significantly reduced in both ADC tissues and cancer cells. The results of relevant clinical studies indicated that down-regulation of was statistically correlated with shorter overall survival time and post-progression survival time. Through analysis of datasets obtained from the Gene Expression Omnibus database, significant low levels of were identified in cisplatin-resistant ADC cells. Moreover, small interfering RNA (siRNA)-mediated knockdown of protein tyrosine kinase 7 (PTK7) elevated the expression of in the ADC cell lines H1299 and H2009. Our work demonstrates that low levels of are specifically found in ADC and that this gene may be a potential therapeutic target for this subset of lung cancers. Determination of the role of in ADC biology would give us some insightful information for further investigations.