Emergency Medicine Department, Glasgow Royal Infirmary, Glasgow G4 0SF, UK.
Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G4 0SF, UK.
Int J Mol Sci. 2018 Jan 5;19(1):157. doi: 10.3390/ijms19010157.
Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. Inherent in the biochemistry of these processes is the role of magnesium, one of the main cellular ions and an essential cofactor in all reactions that use ATP. Magnesium plays an important role in many of the processes involved in regulating telomere structure, integrity and function. This review explores the mechanisms that maintain telomere structure and function, their influence on circadian rhythms and their impact on health and age-related disease. The pervasive role of magnesium in telomere homeostasis is also highlighted.
端粒生物学是衰老标志的一个关键组成部分，它深入了解了与年龄相关的疾病（如癌症）相关的正常衰老过程的失调。端粒稳态与细胞代谢密切相关，特别是与线粒体生理学密切相关，线粒体生理学在细胞衰老和正常生理衰老过程中也会减弱。在这些过程的生物化学中，镁起着重要的作用，镁是主要的细胞离子之一，也是所有使用 ATP 的反应的必需辅助因子。镁在调节端粒结构、完整性和功能的许多过程中发挥着重要作用。这篇综述探讨了维持端粒结构和功能的机制，它们对生物钟节律的影响，以及它们对健康和与年龄相关的疾病的影响。镁在端粒动态平衡中的普遍作用也得到了强调。
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