Sodi Andrea, Bacherini Daniela, Lenzetti Chiara, Caporossi Orsola, Murro Vittoria, Mucciolo Dario Pasquale, Cipollini Francesca, Passerini Ilaria, Virgili Gianni, Rizzo Stanislao
Department of Surgery and Translational Medicine, Eye Clinic, Careggi Teaching Hospital, Florence, Italy.
Department of Genetic Diagnosis, Careggi Teaching Hospital, Florence, Italy.
PLoS One. 2018 Jan 5;13(1):e0190780. doi: 10.1371/journal.pone.0190780. eCollection 2018.
Choroidal thickness (CT) evaluation with EDI-OCT in Stargardt Disease (STGD), considering its possible association with some clinical features of the disease.
CT was evaluated in 41 STGD patients and in 70 controls. Measurements were performed in the subfoveal position and at 1000 μm nasally and temporally. CT average values in STGD and in the control group were first compared by means of Student's T test. Then, the possible association between CT and some clinical features was evaluated by means of linear regression analysis. Considered clinical parameters were: age, age on onset, duration of the disease, visual acuity, foveal thickness, Fishman clinical phenotype, visual field loss and ERG response.
Average CT was not significantly different between controls and STGD patients. In the STGD group the correlation between CT and age (r = 0.22, p = 0.033) and age of onset (r = 0.05, p = 0.424) was modest, while that of CT with disease duration (r = 0.30, p<0.001) was moderate. CT and foveal thickness were also significantly but modestly correlated (r = 0.15, p = 0.033).
In our series average CT is not significantly changed in STGD in comparison with the controls. Nevertheless a choroidal thinning may be identified in the more advanced stages of the disease.
利用增强深度成像光学相干断层扫描（EDI-OCT）评估斯塔加特病（STGD）的脉络膜厚度（CT），并探讨其与该病某些临床特征的可能关联。
对41例STGD患者和70例对照者进行CT评估。在黄斑中心凹下、鼻侧和颞侧1000μm处进行测量。首先通过学生t检验比较STGD组和对照组的CT平均值。然后，通过线性回归分析评估CT与某些临床特征之间的可能关联。考虑的临床参数包括：年龄、发病年龄、病程、视力、黄斑厚度、菲什曼临床表型、视野缺损和视网膜电图反应。
对照组和STGD患者的平均CT无显著差异。在STGD组中，CT与年龄（r = 0.22，p = 0.033）和发病年龄（r = 0.05，p = 0.424）的相关性较弱，而CT与病程（r = 0.30，p<0.001）的相关性中等。CT与黄斑厚度也有显著但较弱的相关性（r = 0.15，p = 0.033）。
在我们的系列研究中，与对照组相比，STGD患者的平均CT无显著变化。然而，在疾病的更晚期可能会发现脉络膜变薄。
