Pediatric Dentistry Unit, Pediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong.
Clin Oral Investig. 2018 Mar;22(2):583-596. doi: 10.1007/s00784-017-2322-9. Epub 2018 Jan 5.
The objective of this study was to evaluate the association between salivary and plaque arginine levels/ADS activities with dental caries.
A systematic search was performed as per PRISMA statement using PubMed, Scopus, Cochrane Library, and Web of Science. Published studies that investigated adults and children (P) with caries-active status (E) and caries-free status (C), whereby arginine levels/ADS activity (O) was measured in saliva/plaque to analyze exposure-outcome association compared to the control group were deemed eligible for inclusion. Quality assessment was performed using combined Newcastle-Ottawa Scale and Modified RTI Item Bank scale. Meta-analysis was performed for effect size, precision estimation, and subgroup effects analysis.
Of 233 records identified, seven (κ = 1.00) were included for qualitative synthesis (systematic review) and four for quantitative synthesis (meta-analysis). No specific bias could be identified in five studies assessed as per the Modified RTI Item Bank scale. Two studies received lower scores on the Newcastle Ottawa scale. Plaque ADS activity in adults (effect size = 0.93, p = 0.008), salivary ADS activity in adults and children (effect size = 0.85, p < 0.001), and salivary ADS activity in adults (effect size = 0.87, p < 0.001) identified a statistically significant effect size. Subgroup analysis demonstrated non-significant variance (Q value = 0.042, p = 0.838) between saliva and plaque ADS activities of adults.
The results of this review suggest the salivary and plaque ADS activities appear to be promising caries risk indicators for adults, while results remain inconclusive in children.
Measuring ADS activities (saliva or plaque) can be a potential caries risk indicator in adults. The protocol was registered on PROSPERO database: CRD42017060701.
本研究旨在评估唾液和菌斑精氨酸水平/ADS 活性与龋齿的关系。
根据 PRISMA 声明，通过 PubMed、Scopus、Cochrane 图书馆和 Web of Science 进行系统搜索。纳入了评估有龋齿活跃状态（E）和无龋齿状态（C）的成年人和儿童（P）的研究，测量唾液/菌斑中的精氨酸水平/ADS 活性（O），并与对照组进行比较，分析暴露-结局关系。使用纽卡斯尔-渥太华量表和改良 RTI 项目库量表进行质量评估。进行效应量的荟萃分析、精度估计和亚组效应分析。
在 233 条记录中，有 7 条（κ=1.00）记录符合定性综合（系统综述）的纳入标准，4 条记录符合定量综合（荟萃分析）的纳入标准。根据改良 RTI 项目库量表评估，五项研究未发现特定偏倚。两项研究在纽卡斯尔-渥太华量表上的得分较低。成人菌斑 ADS 活性（效应量=0.93，p=0.008）、成人和儿童唾液 ADS 活性（效应量=0.85，p<0.001）和成人唾液 ADS 活性（效应量=0.87，p<0.001）均具有统计学意义。亚组分析表明，成人唾液和菌斑 ADS 活性之间无显著差异（Q 值=0.042，p=0.838）。
本综述结果表明，唾液和菌斑 ADS 活性似乎是成人龋齿的有前途的风险指标，而在儿童中结果仍不确定。
测量 ADS 活性（唾液或菌斑）可能是成人龋齿风险的潜在指标。该方案已在 PROSPERO 数据库中注册：CRD42017060701。
