Anticancer efficacy of 2-chloroethylnitrosocarbamoyl derivatives of L-alanine, glycine, their di- and tripeptide homologues and the respective amides in methylnitrosourea-induced rat mammary carcinoma.
作者信息
Klenner T, Berger M R, Eisenbrand G, Schmähl D
机构信息
Institute of Toxicology and Chemotherapy, German Cancer Research Center, FRG.
出版信息
Br J Cancer. 1989 Mar;59(3):335-40. doi: 10.1038/bjc.1989.66.
Abstract
摘要
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Anticancer efficacy of 2-chloroethylnitrosocarbamoyl derivatives of L-alanine, glycine, their di- and tripeptide homologues and the respective amides in methylnitrosourea-induced rat mammary carcinoma.L-丙氨酸、甘氨酸的2-氯乙基亚硝基甲酰基衍生物、其二肽和三肽同系物以及相应酰胺在甲基亚硝基脲诱导的大鼠乳腺癌中的抗癌疗效
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Estrogen-linked 2-chloroethylnitrosoureas: anticancer efficacy in MNU-induced rat mammary carcinoma, uterine activity in mice and receptor interactions.雌激素连接的2-氯乙基亚硝脲：对N-甲基-N-亚硝基脲诱导的大鼠乳腺癌的抗癌疗效、对小鼠子宫的作用及受体相互作用
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Influence of the alkyllysophospholipid ET-18-OCH3 on methylnitrosourea-induced rat mammary carcinomas.
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Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-丙氨酸及其衍生物对小鼠结肠可移植腺癌（MAC）的活性。
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An oestradiol-linked nitrosourea and site-directed chemotherapy in mammary carcinoma.一种雌二醇连接的亚硝基脲与乳腺癌的位点定向化疗。
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In vitro evaluation of an estradiol-linked nitrosourea in mammary carcinomas of mouse, rat and man.雌二醇连接亚硝基脲在小鼠、大鼠和人类乳腺癌中的体外评估。
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引用本文的文献
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Modulation of cytosolic sexual steroid receptors in autochthonous methylnitrosourea-induced rat mammary carcinoma following application of 2-chloroethylnitrosocarbamoyl-L-alanine linked to oestradiol or dihydrotestosterone.在应用与雌二醇或二氢睾酮相连的2-氯乙基亚硝基氨基甲酰-L-丙氨酸后，对原位甲基亚硝基脲诱导的大鼠乳腺癌中细胞溶质性激素受体的调节。
Br J Cancer. 1990 Jul;62(1):42-7. doi: 10.1038/bjc.1990.226.
2
Androgen-linked alkylating agents: biological activity in methylnitrosourea-induced rat mammary carcinoma.雄激素相关烷化剂：在甲基亚硝基脲诱导的大鼠乳腺癌中的生物活性
J Cancer Res Clin Oncol. 1990;116(6):538-49. doi: 10.1007/BF01637072.
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Antineoplastic efficacy of melphalan and N-(2-chloroethyl)-N-nitrosocarbamoyl-omega-lysine, in combination with diazoxide or insulin in autochthonous mammary carcinoma of the Sprague-Dawley rat.美法仑和N-(2-氯乙基)-N-亚硝基氨基甲酰-ω-赖氨酸与二氮嗪或胰岛素联合应用于斯普拉格-道利大鼠自发性乳腺癌的抗肿瘤疗效。
J Cancer Res Clin Oncol. 1990;116(1):45-50. doi: 10.1007/BF01612639.
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Noncarcinogenic chemotherapy with a combination of vincristine, methotrexate and 5-fluorouracil (VMF) in rats.在大鼠中使用长春新碱、甲氨蝶呤和5-氟尿嘧啶（VMF）联合进行非致癌性化疗。
Int J Cancer. 1983 Aug 15;32(2):231-6. doi: 10.1002/ijc.2910320215.
3
Antineoplastic activity of esters and amides of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-aminoacids.N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-氨基酸酯和酰胺的抗肿瘤活性
J Cancer Res Clin Oncol. 1984;108(2):249-51. doi: 10.1007/BF00402478.
4
Anticancer activity of new nitrosoureas against Walder carcinosarcoma 256 and DMBA-induced mammary cancer of the rat.
Oncology. 1980;37(3):177-83. doi: 10.1159/000225430.
5
Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-丙氨酸及其衍生物对小鼠结肠可移植腺癌（MAC）的活性。
J Cancer Res Clin Oncol. 1986;112(1):47-9. doi: 10.1007/BF00394938.
6
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New derivatives of CNC-amino acids and -oligopeptides: experimental antitumor activity.CNC-氨基酸和-寡肽的新衍生物：实验性抗肿瘤活性。
J Cancer Res Clin Oncol. 1986;111(2):154-6. doi: 10.1007/BF00400755.
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Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222.将四种新合成的2-氯乙基亚硝脲与卡莫司汀、洛莫司汀、司莫司汀、链脲佐菌素和羟乙基亚硝脲在晚期大鼠白血病L 5222中进行比较研究。
J Cancer Res Clin Oncol. 1979 Sep;95(1):43-9. doi: 10.1007/BF00411108.
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