N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-丙氨酸及其衍生物对小鼠结肠可移植腺癌（MAC）的活性。
Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).
作者信息
Bibby M C, Double J A
出版信息
J Cancer Res Clin Oncol. 1986;112(1):47-9. doi: 10.1007/BF00394938.
Abstract
The anti-neoplastic activity of N-[N'-(2-chloroethyl)-N-nitrosocarbamoyl(CNC)]-alanine, CNC-alanyl-alanine, CNC-alanine-methylamide and CNC-glycine-methylamide was examined in murine transplantable colon tumours (MAC). The methylamide derivatives were highly active against a solid adenocarcinoma (MAC 13) and an ascitic adenocarcinoma (MAC 15 A). CNC-alanyl-alanine was also highly active against MAC 15 A. Responses of the three latter agents against the ascitic tumour were better than for any previously tested drugs including the nitrosoureas but their eventual usefulness cannot be determined without further toxicological studies.
摘要
研究了N-[N'-(2-氯乙基)-N-亚硝基氨基甲酰基（CNC）]-丙氨酸、CNC-丙氨酰-丙氨酸、CNC-丙氨酸-甲酰胺和CNC-甘氨酸-甲酰胺对小鼠可移植性结肠肿瘤（MAC）的抗肿瘤活性。甲酰胺衍生物对实体腺癌（MAC 13）和腹水腺癌（MAC 15 A）具有高活性。CNC-丙氨酰-丙氨酸对MAC 15 A也具有高活性。后三种药物对腹水肿瘤的反应比包括亚硝基脲类在内的任何先前测试的药物都要好，但在没有进一步毒理学研究的情况下，无法确定它们最终的实用性。
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本文引用的文献
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