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人类免疫缺陷病毒耐药性检测技术及其在非洲资源有限地区的适用性

Human Immunodeficiency Virus Resistance Testing Technologies and Their Applicability in Resource-Limited Settings of Africa.

作者信息

Nasir Idris Abdullahi, Emeribe Anthony Uchenna, Ojeamiren Iduda, Aderinsayo Adekola Hafeez

机构信息

Department of Medical Microbiology and Parasitology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.

Department of Medical Laboratory Services, University of Abuja Teaching Hospital, FCT Abuja, Nigeria.

出版信息

Infect Dis (Auckl). 2017 Dec 19;10:1178633717749597. doi: 10.1177/1178633717749597. eCollection 2017.

DOI:10.1177/1178633717749597
PMID:29308013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5751912/
Abstract

There has been tremendous breakthrough in the development of technologies and protocols for counselling, testing, and surveillance of resistant human immunodeficiency virus strains for efficient prognosis and clinical management aimed at improving the quality of life of infected persons. However, we have not arrived at a point where services rendered using these technologies can be made affordable and accessible to resource-limited settings. There are several technologies for monitoring antiretroviral resistance, each with unique merits and demerits. In this study, we review the strengths and limitations of prospective and affordable technologies with emphasis on those that could be used in resource-limited settings.

摘要

在用于咨询、检测和监测耐药人类免疫缺陷病毒株以进行有效预后和临床管理的技术及方案的开发方面,已经取得了巨大突破,旨在提高感染者的生活质量。然而,我们尚未达到这样一种程度,即使用这些技术提供的服务能够让资源有限的地区负担得起并可获得。有几种监测抗逆转录病毒耐药性的技术,每种技术都有独特的优缺点。在本研究中,我们回顾了前瞻性且经济实惠的技术的优势和局限性,重点关注那些可在资源有限地区使用的技术。

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本文引用的文献

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Lancet Infect Dis. 2016 Nov;16(11):e267-e275. doi: 10.1016/S1473-3099(16)30118-9. Epub 2016 Aug 25.
3
The need for second-line antiretroviral therapy in adults in sub-Saharan Africa up to 2030: a mathematical modelling study.撒哈拉以南非洲地区成年人到 2030 年需要二线抗逆转录病毒治疗:一项数学建模研究。
Lancet HIV. 2016 Mar;3(3):e132-9. doi: 10.1016/S2352-3018(16)00016-3. Epub 2016 Feb 16.
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Contribution of Gag and Protease to HIV-1 Phenotypic Drug Resistance in Pediatric Patients Failing Protease Inhibitor-Based Therapy.在接受基于蛋白酶抑制剂治疗失败的儿科患者中,Gag和蛋白酶对HIV-1表型耐药性的作用。
Antimicrob Agents Chemother. 2016 Mar 25;60(4):2248-56. doi: 10.1128/AAC.02682-15. Print 2016 Apr.
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HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.HIV-1耐药性突变:即时检验基因分型耐药性检测的潜在应用
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