Fareed Ahmed, Vavere Andrea L, Zimmermann Elke, Tanami Yutaka, Steveson Chloe, Matheson Matthew, Paul Narinder, Clouse Melvin, Cox Christopher, Lima João A C, Arbab-Zadeh Armin
Department of Medicine/Cardiology Division, Johns Hopkins University, Baltimore, MD Department of Medicine/Cardiology Division, Suez Canal University, Ismailia, Egypt Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany Toshiba Medical Systems, Otawara, Minato-Ku, Tokyo, Japan Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Joint Department of Medical Imaging, Toronto General Hospital, Toronto, Canada Beth Israel Deaconess Medical Center, Harvard University, Boston, MA.
Medicine (Baltimore). 2017 Dec;96(48):e8452. doi: 10.1097/MD.0000000000008452.
Iterative reconstruction has been shown to reduce image noise compared with traditional filtered back projection with quantum denoising software (FBP/QDS+) in CT imaging but few comparisons have been made in the same patients without the influence of interindividual factors. The objective of this study was to investigate the impact of adaptive iterative dose reduction in 3-dimensional (AIDR 3D) and FBP/QDS+-based image reconstruction on image quality in the same patients.We randomly selected 100 patients enrolled in the coronary evaluation using 320-slice CT study who underwent CT coronary angiography using prospectively electrocardiogram triggered image acquisition with a 320-detector scanner. Both FBP/QDS+ and AIDR 3D reconstructions were performed using original data. Studies were blindly analyzed for image quality by measuring the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). Image quality was assessed qualitatively using a 4-point scale.Median age was 63 years (interquartile range [IQR]: 56-71) and 72% were men, median body mass index 27 (IQR: 24-30) and median calcium score 222 (IQR: 11-644). For all regions of interest, mean image noise was lower for AIDR 3D vs. FBP/QDS+ (31.69 vs. 34.37, P ≤ .001). SNR and CNR were significantly higher for AIDR 3D vs. FBP/QDS+ (16.28 vs. 14.64, P < .001 and 19.21 vs. 17.06, P < .001, respectively). Subjective (qualitative) image quality scores were better using AIDR 3D vs. FBP/QDS+ with means of 1.6 and 1.74, respectively (P ≤ .001).Assessed in the same individuals, iterative reconstruction decreased image noise and raised SNR/CNR as well as subjective image quality scores compared with traditional FBP/QDS+ in 320-slice CT coronary angiography at standard radiation doses.
与传统的带有量子降噪软件的滤波反投影（FBP/QDS+）相比，迭代重建已被证明在CT成像中可降低图像噪声，但在同一患者中，且不受个体因素影响的情况下，很少进行比较。本研究的目的是调查三维自适应迭代剂量降低（AIDR 3D）和基于FBP/QDS+的图像重建对同一患者图像质量的影响。我们随机选择了100名参与使用320层CT进行冠状动脉评估研究的患者，这些患者使用320探测器扫描仪进行前瞻性心电图触发图像采集的CT冠状动脉造影。FBP/QDS+和AIDR 3D重建均使用原始数据。通过测量信噪比（SNR）和对比噪声比（CNR）对研究进行盲法图像质量分析。使用4分制对图像质量进行定性评估。中位年龄为63岁（四分位间距[IQR]：56 - 71），72%为男性，中位体重指数为27（IQR：24 - 30），中位钙积分为222（IQR：11 - 644）。对于所有感兴趣区域，AIDR 3D的平均图像噪声低于FBP/QDS+（31.69对34.37，P≤0.001）。AIDR 3D的SNR和CNR显著高于FBP/QDS+（分别为16.28对14.64，P<0.001和19.21对17.06，P<0.001）。使用AIDR 3D的主观（定性）图像质量评分优于FBP/QDS+，均值分别为1.6和1.74（P≤0.001）。在同一患者中进行评估时，与标准辐射剂量下320层CT冠状动脉造影中传统的FBP/QDS+相比，迭代重建降低了图像噪声，提高了SNR/CNR以及主观图像质量评分。
