2014-2016 年巴西皮奥伊州吉兰-巴雷综合征患者近期感染的血清学标志物。
Serological Markers of Recent Infection in Patients with Guillain-Barré Syndrome in the State of Piauí, Brazil, 2014-2016.
机构信息
Department of Bacteriology and Mycology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
Post-graduation Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
出版信息
Am J Trop Med Hyg. 2018 Feb;98(2):586-588. doi: 10.4269/ajtmh.17-0666. Epub 2018 Jan 4.
In countries where poliomyelitis has been eradicated, Guillain-Barré syndrome (GBS) is the leading cause of acute flaccid paralysis. The range of infections that precede GBS in Brazil is unknown. infection is the most frequent trigger of GBS worldwide. Given the lack of systematic surveillance of diarrheal diseases, particularly in adults, the incidence of enteritis caused by in developing countries is unknown. From 2014 to 2016, pretreatment serum samples from 63 GBS patients were tested by immunoglobulin M (IgM) enzyme-linked immunosorbent assay for . IgM antibodies were detected in 17% (11/63) of the samples. There was no association between serological positivity (IgM) for and the occurrence of diarrhea among the investigated cases ( = 0.36). Hygiene measures, basic sanitation, and precautions during handling and preparation of food of animal origin may help prevent acute flaccid paralysis.
在已经消灭脊髓灰质炎的国家，吉兰-巴雷综合征（GBS）是导致急性弛缓性麻痹的主要原因。巴西境内导致 GBS 出现的感染范围尚不清楚。感染是全球范围内最常见的 GBS 触发因素。由于对腹泻病（尤其是成人）缺乏系统监测，发展中国家由 引起的肠炎发病率尚不清楚。2014 年至 2016 年，对 63 例 GBS 患者的治疗前血清样本进行了免疫球蛋白 M（IgM）酶联免疫吸附试验，以检测 。在 17%（11/63）的样本中检测到 IgM 抗体。在所调查病例中，血清学阳性（IgM）与腹泻的发生之间没有关联（=0.36）。卫生措施、基本环境卫生以及在处理和准备动物源性食品时的预防措施，可能有助于预防急性弛缓性麻痹。
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