局部用氧治疗慢性伤口：支持与反对的辩论
Topical Oxygen for Chronic Wounds: A PRO/CON Debate.
作者信息
Mutluoglu Mesut, Cakkalkurt Aslican, Uzun Gunalp, Aktas Samil
机构信息
Department of Underwater and Hyperbaric Medicine, GATA Haydarpasa Teaching Hospital, 34668 Uskudar, Istanbul, Turkey.
Department of Underwater and Hyperbaric Medicine, Ankara Numune Teaching and Research Hospital, Ankara, Turkey.
出版信息
J Am Coll Clin Wound Spec. 2014 Dec 19;5(3):61-5. doi: 10.1016/j.jccw.2014.12.003. eCollection 2013 Dec.
Abstract
The role of oxygen in wound healing is universally accepted and does not require any further evidence; however the controversy as to whether oxygen delivery systems have the potential to improve wound healing remains to be concluded. Topical oxygen treatment (TOT) involves the delivery of 100% oxygen for a mean of 90 min, once a day at an atmospheric pressure slightly above 1 atm abs. The use of TOT gained increasing interest recently. The current manuscript will summarize the pros and cons of TOT in the view of the available literature.
摘要
氧气在伤口愈合中的作用已得到普遍认可，无需进一步论证；然而，关于氧气输送系统是否有潜力促进伤口愈合的争议仍有待定论。局部氧疗（TOT）是指在略高于1个绝对大气压的环境下，每天一次输送100%的氧气，平均持续90分钟。最近，TOT的应用越来越受到关注。本手稿将根据现有文献总结TOT的优缺点。
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本文引用的文献
1
2
Evidence-based practice standards for the use of topical pressurised oxygen therapy.局部加压氧治疗的循证实践标准。
Int Wound J. 2012 Jun;9(3):271-84. doi: 10.1111/j.1742-481X.2012.00956.x. Epub 2012 Apr 11.
3
Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: a prospective controlled study.局部伤口氧疗治疗重度糖尿病足溃疡：一项前瞻性对照研究。
Ostomy Wound Manage. 2010 Jun;56(6):24-31.
4
Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds.局部氧疗可诱导血管内皮生长因子表达，并促进临床出现的慢性伤口愈合。
Clin Exp Pharmacol Physiol. 2008 Aug;35(8):957-64. doi: 10.1111/j.1440-1681.2008.04934.x. Epub 2008 Apr 21.
5
Oxygen therapy and wound healing--topical oxygen is not hyperbaric oxygen therapy.氧疗与伤口愈合——局部用氧并非高压氧疗法。
S Afr Med J. 2005 Nov;95(11):840.
6
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Undersea Hyperb Med. 2005 May-Jun;32(3):157-68.
7
Topical oxygen is not hyperbaric oxygen (HBO2).局部用氧并非高压氧（HBO₂）。
Undersea Hyperb Med. 2003 Winter;30(4):267-9.
8
Revisiting the essential role of oxygen in wound healing.重新审视氧气在伤口愈合中的重要作用。
Am J Surg. 2003 Sep;186(3):259-63. doi: 10.1016/s0002-9610(03)00211-3.
9
Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1).原代心脏成纤维细胞的氧感知：p21（Waf1/Cip1/Sdi1）的关键作用
Circ Res. 2003 Feb 21;92(3):264-71. doi: 10.1161/01.res.0000056770.30922.e6.
10
Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm.伤口愈合中的氧气、氧化剂与抗氧化剂：一种新兴范式。
Ann N Y Acad Sci. 2002 May;957:239-49. doi: 10.1111/j.1749-6632.2002.tb02920.x.
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