肌浆网钙 ATP 酶 2b 介导棕色脂肪产热的非解耦联蛋白 1 依赖性途径
SERCA2b Cycles Its Way to UCP1-Independent Thermogenesis in Beige Fat.
机构信息
Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, MI 48202, USA.
Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, MI 48202, USA.
出版信息
Cell Metab. 2018 Jan 9;27(1):7-9. doi: 10.1016/j.cmet.2017.12.015.
PMID:29320712
Abstract
A new study in Nature Medicine, by Ikeda et al. (2017), reports that calcium cycling in beige adipocytes elevates energy expenditure and glucose oxidation in the absence of uncoupling protein 1. Thermogenic calcium cycling in beige fat is mediated by SERCA2b and improves cold tolerance and metabolic status.
摘要
一项发表在《自然医学》上的由池田等人（2017 年）进行的新研究表明，米色脂肪细胞中的钙循环在没有解偶联蛋白 1 的情况下会提高能量消耗和葡萄糖氧化。米色脂肪中的产热钙循环由 SERCA2b 介导，并能改善耐寒性和代谢状态。
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