淋病奈瑟菌对庆大霉素的敏感性-淋病分离株监测项目，2015-2016 年。
Susceptibility of Neisseria gonorrhoeae to Gentamicin-Gonococcal Isolate Surveillance Project, 2015-2016.
机构信息
From the Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
出版信息
Sex Transm Dis. 2018 Feb;45(2):96-98. doi: 10.1097/OLQ.0000000000000693.
Abstract
The gentamicin minimum inhibitory concentrations (MICs) of Neisseria gonorrhoeae isolates were determined. Seventy-three percent of isolates demonstrated an MIC range of 8 to 16 μg/mL, and 27% demonstrated an MIC of 4 μg/mL or less. Significant associations between gentamicin MIC and resistance or reduced susceptibility to other antimicrobials were found.
摘要
对淋病奈瑟菌分离株的庆大霉素最小抑菌浓度（MIC）进行了测定。73%的分离株的 MIC 范围为 8 至 16μg/ml，27%的分离株的 MIC 为 4μg/ml 或更低。发现庆大霉素 MIC 与其他抗菌药物的耐药性或降低敏感性之间存在显著关联。
相似文献
1
Susceptibility of Neisseria gonorrhoeae to Gentamicin-Gonococcal Isolate Surveillance Project, 2015-2016.淋病奈瑟菌对庆大霉素的敏感性-淋病分离株监测项目，2015-2016 年。
Sex Transm Dis. 2018 Feb;45(2):96-98. doi: 10.1097/OLQ.0000000000000693.
2
Efficacy of Gentamicin Alone and in Combination with Ceftriaxone, Ertapenem, and Azithromycin against Multidrug-Resistant Neisseria gonorrhoeae.单独使用庆大霉素以及联合使用头孢曲松、厄他培南和阿奇霉素对抗耐多药淋病奈瑟菌的疗效。
Microbiol Spectr. 2021 Oct 31;9(2):e0018121. doi: 10.1128/Spectrum.00181-21. Epub 2021 Oct 20.
3
Neisseria gonorrhoeae Antimicrobial Susceptibility Surveillance - The Gonococcal Isolate Surveillance Project, 27 Sites, United States, 2014.淋病奈瑟菌抗菌药物敏感性监测 - 淋球菌分离株监测项目，美国 27 个监测点，2014 年。
MMWR Surveill Summ. 2016 Jul 15;65(7):1-19. doi: 10.15585/mmwr.ss6507a1.
4
Is gentamicin a viable therapeutic option for treating resistant Neisseria gonorrhoeae in New South Wales?庆大霉素治疗新南威尔士耐淋病奈瑟菌感染是否可行？
Commun Dis Intell (2018). 2021 Feb 26;45. doi: 10.33321/cdi.2021.45.12.
5
Development of an antimicrobial susceptibility surveillance system for Neisseria gonorrhoeae in Malawi: comparison of methods.马拉维淋病奈瑟菌抗菌药物敏感性监测系统的建立：方法比较
J Clin Microbiol. 1997 Nov;35(11):2985-8. doi: 10.1128/jcm.35.11.2985-2988.1997.
6
Trends in antimicrobial resistance in Neisseria gonorrhoeae in the USA: the Gonococcal Isolate Surveillance Project (GISP), January 2006-June 2012.美国淋病奈瑟菌的抗菌药物耐药趋势：淋球菌分离监测项目（GISP），2006 年 1 月-2012 年 6 月。
Sex Transm Infect. 2013 Dec;89 Suppl 4:iv5-10. doi: 10.1136/sextrans-2013-051162.
7
Surveillance of the Antimicrobial Susceptibility of Neisseria gonorrhoeae Isolates Collected in Changsha, China from 2003 to 2015.2003年至2015年中国长沙淋病奈瑟菌分离株抗菌药物敏感性监测
Jpn J Infect Dis. 2017 Sep 25;70(5):518-521. doi: 10.7883/yoken.JJID.2016.522. Epub 2017 Mar 28.
8
Associations between antimicrobial susceptibility/resistance of Neisseria gonorrhoeae isolates in European Union/European Economic Area and patients' gender, sexual orientation and anatomical site of infection, 2009-2016.2009-2016 年，欧盟/欧洲经济区淋病奈瑟菌分离株的抗菌药物敏感性/耐药性与患者的性别、性取向和感染解剖部位的关系。
BMC Infect Dis. 2021 Mar 18;21(1):273. doi: 10.1186/s12879-021-05931-0.
9
Stably high azithromycin resistance and decreasing ceftriaxone susceptibility in Neisseria gonorrhoeae in 25 European countries, 2016.25 个欧洲国家 2016 年淋病奈瑟菌稳定高阿奇霉素耐药率和头孢曲松敏感性下降
BMC Infect Dis. 2018 Dec 3;18(1):609. doi: 10.1186/s12879-018-3528-4.
10
Antimicrobial Susceptibility of Urogenital and Extragenital Neisseria gonorrhoeae Isolates Among Men Who Have Sex With Men: Strengthening the US Response to Resistant Gonorrhea and Enhanced Gonococcal Isolate Surveillance Project, 2018 to 2019.男男性行为人群中泌尿生殖道和生殖外淋病奈瑟菌分离株的抗菌药物敏感性：加强美国对抗耐药淋病的应对措施和增强淋球菌分离株监测项目，2018 至 2019 年。
Sex Transm Dis. 2021 Dec 1;48(12S Suppl 2):S111-S117. doi: 10.1097/OLQ.0000000000001548.
引用本文的文献
1
antimicrobial susceptibility testing: application of traditional agar dilution to a high-throughput 96-well microtiter assay.抗菌药物敏感性试验：传统琼脂稀释法在高通量96孔微量滴定分析中的应用。
Microbiol Spectr. 2025 Jul;13(7):e0324924. doi: 10.1128/spectrum.03249-24. Epub 2025 Jun 9.
2
Common Patterns and Unique Threats in Antimicrobial Resistance as Demonstrated by Global Gonococcal Surveillance.全球淋球菌监测显示的抗菌药物耐药常见模式和特有威胁
Emerg Infect Dis. 2024 Oct;30(14):62-70. doi: 10.3201/eid3014.240296.
3
Global trends of antimicrobial resistance rates in : a systematic review and meta-analysis.全球抗菌药物耐药率趋势：一项系统评价与荟萃分析
Front Pharmacol. 2024 Jul 3;15:1284665. doi: 10.3389/fphar.2024.1284665. eCollection 2024.
4
Increase in Multidrug Resistant FC428-Like Isolates Harboring the Mosaic penA 60.001 Gene, in Nanjing, China (2017-2020).中国南京（2017 - 2020年）携带嵌合型penA 60.001基因的多重耐药FC428样分离株增加。
Infect Drug Resist. 2023 Jun 23;16:4053-4064. doi: 10.2147/IDR.S408896. eCollection 2023.
5
High-level in vitro resistance to gentamicin acquired in a stepwise manner in Neisseria gonorrhoeae.淋病奈瑟菌逐步获得庆大霉素高水平体外耐药性。
J Antimicrob Chemother. 2023 Jul 5;78(7):1769-1778. doi: 10.1093/jac/dkad168.
6
Surveillance systems to monitor antimicrobial resistance in : a global, systematic review, 1 January 2012 to 27 September 2020.监测抗菌药物耐药性的监测系统：2012 年 1 月 1 日至 2020 年 9 月 27 日的全球系统评价。
Euro Surveill. 2022 May;27(18). doi: 10.2807/1560-7917.ES.2022.27.18.2100917.
7
A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in .一个氨基酸取代延伸因子 G 可导致. 对庆大霉素的低度耐药性。
Antimicrob Agents Chemother. 2022 May 17;66(5):e0025122. doi: 10.1128/aac.00251-22. Epub 2022 Apr 25.
8
Efficacy of Gentamicin Alone and in Combination with Ceftriaxone, Ertapenem, and Azithromycin against Multidrug-Resistant Neisseria gonorrhoeae.单独使用庆大霉素以及联合使用头孢曲松、厄他培南和阿奇霉素对抗耐多药淋病奈瑟菌的疗效。
Microbiol Spectr. 2021 Oct 31;9(2):e0018121. doi: 10.1128/Spectrum.00181-21. Epub 2021 Oct 20.
9
Antimicrobial susceptibility of in Barcelona during a five-year period, 2013 to 2017.2013 年至 2017 年期间巴塞罗那地区 的药敏情况。
Euro Surveill. 2020 Oct;25(42). doi: 10.2807/1560-7917.ES.2020.25.42.1900576.
10
The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae.解决淋病奈瑟菌抗生素耐药性的前沿问题。
Transl Res. 2020 Jun;220:122-137. doi: 10.1016/j.trsl.2020.02.002. Epub 2020 Feb 29.
本文引用的文献
1
Neisseria gonorrhoeae Antimicrobial Susceptibility Surveillance - The Gonococcal Isolate Surveillance Project, 27 Sites, United States, 2014.淋病奈瑟菌抗菌药物敏感性监测 - 淋球菌分离株监测项目，美国 27 个监测点，2014 年。
MMWR Surveill Summ. 2016 Jul 15;65(7):1-19. doi: 10.15585/mmwr.ss6507a1.
2
Comparison of antimicrobial susceptibilities of pharyngeal, rectal, and urethral Neisseria gonorrhoeae isolates among men who have sex with men.男男性行为者中咽部、直肠和尿道淋病奈瑟菌分离株的抗菌药物敏感性比较。
Antimicrob Agents Chemother. 2015 May;59(5):2588-95. doi: 10.1128/AAC.04476-14. Epub 2015 Feb 17.
3
The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea.庆大霉素联合阿奇霉素以及吉米沙星联合阿奇霉素治疗单纯性淋病的疗效与安全性。
Clin Infect Dis. 2014 Oct 15;59(8):1083-91. doi: 10.1093/cid/ciu521. Epub 2014 Jul 16.
4
Cephalosporin and azithromycin susceptibility in Neisseria gonorrhoeae isolates by site of infection, British Columbia, 2006 to 2011.2006 年至 2011 年不列颠哥伦比亚省不同感染部位淋病奈瑟菌分离株头孢菌素和阿奇霉素药敏性。
Sex Transm Dis. 2013 Jan;40(1):46-51. doi: 10.1097/OLQ.0b013e31827bd64c.
5
Cephalosporin resistant Neisseria gonorrhoeae: time to consider gentamicin?耐头孢菌素淋病奈瑟菌：是时候考虑庆大霉素了？
Sex Transm Infect. 2012 Feb;88(1):6-8. doi: 10.1136/sextrans-2011-050362.
6
An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe.欧洲淋病奈瑟菌分离株的庆大霉素敏感性评价。
J Antimicrob Chemother. 2011 Mar;66(3):592-5. doi: 10.1093/jac/dkq476. Epub 2010 Dec 14.
7
Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007.2007 年马拉维利隆圭淋病奈瑟菌的药敏性。
Sex Transm Dis. 2010 Mar;37(3):169-72. doi: 10.1097/OLQ.0b013e3181bf575c.
8
The use of cephalosporins for gonorrhea: the impending problem of resistance.头孢菌素用于淋病治疗：迫在眉睫的耐药性问题。
Expert Opin Pharmacother. 2009 Mar;10(4):555-77. doi: 10.1517/14656560902731993.
9
Emerging antimicrobial resistance in Neisseria gonorrhoeae: urgent need to strengthen prevention strategies.淋病奈瑟菌新出现的抗菌药物耐药性：迫切需要加强预防策略。
Ann Intern Med. 2008 Apr 15;148(8):606-13. doi: 10.7326/0003-4819-148-8-200804150-00005.
10
Cephalosporin allergy.头孢菌素过敏。
N Engl J Med. 2001 Sep 13;345(11):804-9. doi: 10.1056/NEJMra993637.
Zotero 插件