Daly C C, Hoffman I, Hobbs M, Maida M, Zimba D, Davis R, Mughogho G, Cohen M S
John Snow, Inc., Boston, Massachusetts, USA.
J Clin Microbiol. 1997 Nov;35(11):2985-8. doi: 10.1128/jcm.35.11.2985-2988.1997.
Susceptibility of Neisseria gonorrhoeae to gentamicin, the primary treatment for gonorrhea in Malawi since 1993, was determined by using agar dilution MICs, E-test MICs, disc diffusion, and clinical cure rate. Agar dilution MICs were slightly higher in 1996 than in 1993 isolates, with a concomitant drop in the clinical cure rate. E-test MICs were substantially lower than agar dilution determinations, with only 77.4% within 1 log2 concentration.
自1993年以来,庆大霉素一直是马拉维淋病的主要治疗药物,通过琼脂稀释法测定最低抑菌浓度(MIC)、E-test法测定MIC、纸片扩散法及临床治愈率来确定淋病奈瑟菌对庆大霉素的敏感性。1996年分离株的琼脂稀释法MIC略高于1993年的分离株,同时临床治愈率有所下降。E-test法测定的MIC显著低于琼脂稀释法测定的结果,在1个对数2浓度范围内的仅占77.4%。