健康受试者和水肿患者血浆中免疫反应性心房利钠因子的水平。
Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema.
作者信息
Shenker Y, Sider R S, Ostafin E A, Grekin R J
出版信息
J Clin Invest. 1985 Oct;76(4):1684-7. doi: 10.1172/JCI112154.
Abstract
Atrial natriuretic factor (ANF), a recently sequenced cardiac peptide, has been shown to have potent natriuretic, diuretic, and vasodilating effects in several species. We have developed a radioimmunoassay to measure the levels of immunoreactive ANF in human plasma. Plasma levels of ANF in healthy volunteers on a low sodium diet were 9.8 +/- 1.4 pmol/liter and increased to 21.9 +/- 3.0 on a high sodium diet. The levels of atrial natriuretic factor correlated directly with urinary sodium and inversely with plasma renin activity and plasma aldosterone levels. Patients with marked edema due to congestive heart failure had plasma levels of atrial natriuretic factor five times higher than normal (P less than 0.05), whereas patients with cirrhosis and edema had levels that were not different from normal. These results suggest that atrial natriuretic factor plays an important role in the adaptation to increased sodium intake.
摘要
心房利钠因子（ANF）是一种最近测序的心脏肽，已证明在几种物种中具有强大的利钠、利尿和血管舒张作用。我们开发了一种放射免疫测定法来测量人血浆中免疫反应性ANF的水平。低钠饮食的健康志愿者血浆ANF水平为9.8±1.4 pmol/升，高钠饮食时升至21.9±3.0。心房利钠因子水平与尿钠直接相关，与血浆肾素活性和血浆醛固酮水平呈负相关。因充血性心力衰竭导致明显水肿的患者，其血浆心房利钠因子水平比正常高五倍（P<0.05），而肝硬化和水肿患者的水平与正常无异。这些结果表明，心房利钠因子在适应钠摄入增加方面起重要作用。
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