Sicchieri Fernanda, Silva Aline Bomfim, Silva Ana Carolina Japur de Sá Rosa E, Navarro Paula Andrea de Albuquerque Sales, Ferriani Rui Alberto, Reis Rosana Maria Dos
Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, São Paulo University, Brazil.
JBRA Assist Reprod. 2018 Mar 1;22(1):2-7. doi: 10.5935/1518-0557.20180002.
This study aimed to evaluate the clinical pregnancy rate of intrauterine insemination cycles in relation to patient age, cause of infertility, ovulation induction method, number of mature follicles and sperm with progressive motility.
This retrospective observational study included 237 intrauterine insemination cycles performed from 2011 to 2015 at the Assisted Reproduction Service of the Hospital das Clínicas of the Ribeirão Preto Medical School, University of São Paulo. Student's t-test was used to compare quantitative variables and the chi-square test was used to compare qualitative variables.
Patient age was inversely and significantly correlated with pregnancy rates (p=0.001) (Pregnant women = 32.56±5.64 years, non-pregnant women = 36.64±5.03 years). Cause of infertility, ovulation induction method, number of mature follicles and sperm with progressive motility were not associated with pregnancy rates. The overall clinical pregnancy rate was 7.59%. In the subgroup of patients (n=102 cycles) considered ideal for intrauterine insemination (age ≤35 years, unexplained infertility, ovarian factor infertility or minimal endometriosis, and a partner with sperm count ≥2.5 × 10 retrieved on the day of insemination) the pregnancy rate was 12.74%.
In the studied group, female patient age was the only variable significantly correlated with intrauterine insemination success rates.
本研究旨在评估宫腔内人工授精周期的临床妊娠率与患者年龄、不孕原因、促排卵方法、成熟卵泡数量及具有前向运动能力的精子数量之间的关系。
这项回顾性观察性研究纳入了2011年至2015年在圣保罗大学里贝朗普雷图医学院临床医院辅助生殖科进行的237个宫腔内人工授精周期。采用学生t检验比较定量变量，采用卡方检验比较定性变量。
患者年龄与妊娠率呈显著负相关（p = 0.001）（孕妇年龄=32.56±5.64岁，未孕女性年龄=36.64±5.03岁）。不孕原因、促排卵方法、成熟卵泡数量及具有前向运动能力的精子数量与妊娠率无关。总体临床妊娠率为7.59%。在被认为适合宫腔内人工授精的患者亚组（n = 102个周期）中（年龄≤35岁、不明原因不孕、卵巢因素不孕或轻度子宫内膜异位症，且授精当天男方精子计数≥2.5×10），妊娠率为12.74%。
在研究组中，女性患者年龄是唯一与宫腔内人工授精成功率显著相关的变量。
