Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P.R. China.
School of Foreign Languages, Southwest Medical University, Luzhou 646000, P.R. China.
Oncol Rep. 2018 Mar;39(3):893-900. doi: 10.3892/or.2018.6206. Epub 2018 Jan 10.
Tumor immunotherapy has been in development for more than a century. With the rapid developments in biotechnology research in recent years, immunotherapy has become a promising oncotherapy strategy after surgery, chemotherapy and radiotherapy. Cancer vaccines are a promising new treatment strategy and the application of nanotechnology in cancer vaccines, greatly enhances their effectiveness. Such applications indicate the bright prospects of tumor immunotherapy. The multifunctional nanomaterials used in cancer vaccines and their practical application in specific cancer vaccines are hereby reviewed. In addition, a preliminary analysis of the current and prospective use of nanotechnology with the purpose of providing solutions to cancer vaccine challenges is presented.
肿瘤免疫疗法的发展已经超过一个世纪。近年来，随着生物技术研究的快速发展，免疫疗法已经成为继手术、化疗和放疗之后有前途的肿瘤治疗策略。癌症疫苗是一种很有前途的新治疗策略，纳米技术在癌症疫苗中的应用大大提高了它们的疗效。这些应用表明肿瘤免疫疗法前景光明。本文综述了癌症疫苗中使用的多功能纳米材料及其在特定癌症疫苗中的实际应用。此外，还对纳米技术的当前和未来应用进行了初步分析，旨在为癌症疫苗的挑战提供解决方案。
