Werner E, Cheong G K, Gupta D, Dorfman K D, Mehlig B
Department of Physics, University of Gothenburg, SE-41296 Gothenburg, Sweden.
Department of Chemical Engineering and Materials Science, University of Minnesota-Twin Cities, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, USA.
Phys Rev Lett. 2017 Dec 29;119(26):268102. doi: 10.1103/PhysRevLett.119.268102. Epub 2017 Dec 28.
Experiments measuring DNA extension in nanochannels are at odds with even the most basic predictions of current scaling arguments for the conformations of confined semiflexible polymers such as DNA. We show that a theory based on a weakly self-avoiding, one-dimensional "telegraph" process collapses experimental data and simulation results onto a single master curve throughout the experimentally relevant region of parameter space and explains the mechanisms at play.
在纳米通道中测量DNA伸展的实验结果，甚至与当前关于诸如DNA等受限半柔性聚合物构象的标度论证的最基本预测都不一致。我们表明，一种基于弱自回避的一维“电报式”过程的理论，能将实验数据和模拟结果在整个实验相关的参数空间区域内归并到一条单一的主曲线上，并解释其中起作用的机制。
