Tam Dao Ngoc Hien, Truong Duy Hieu, Nguyen Thi Thanh Hoa, Quynh Le Nhat, Tran Linh, Nguyen Hong Duong, Shamandy Bahaa Eldin, Le Thi Minh Huong, Tran Dang Khoa, Sayed Dina, Vu Van Vinh, Mizukami Shusaku, Hirayama Kenji, Huy Nguyen Tien
Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.
Planta Med. 2018 Feb;84(3):139-152. doi: 10.1055/s-0043-124087. Epub 2018 Jan 12.
Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from and studies regardless of publication language and study design. Upon applying the inclusion and exclusion criteria, we included a total of 57 studies for our systemic review. Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. The cytotoxic effects of ginsenoside Rh1 were dependent on different types of cell lines. Other pharmacological effects including estrogenic, enzymatic, anti-microorganism activities, and cardiovascular effects have been mentioned, but the results were considerably diverged. A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.
人参皂苷Rh1是从红参中提取的主要生物活性化合物之一，在全球范围内越来越多地被用于提高认知能力和促进身体健康。本研究的目的是系统地综述人参皂苷Rh1的药理作用。我们在八个电子数据库中进行了检索，包括MEDLINE（PubMed）、Scopus、谷歌学术、POPLINE、全球健康图书馆、虚拟健康图书馆、欧洲灰色文献信息系统和纽约医学院灰色文献报告，以选择报告人参皂苷Rh1从[具体时间范围]和[具体时间范围]研究中的生物学和药理作用的原始研究出版物，无论其出版语言和研究设计如何。在应用纳入和排除标准后，我们共纳入了57项研究进行系统评价。人参皂苷Rh1具有抗炎、抗氧化、免疫调节作用以及对神经系统的积极作用等显著特性。人参皂苷Rh1的细胞毒性作用取决于不同类型的细胞系。还提到了其他药理作用，包括雌激素样、酶活性、抗微生物活性和心血管作用，但结果差异很大。强烈建议开展更高质量的临床试验研究证据，以证实人参皂苷Rh1疗效的一致性。
