Laboratory for Lipidomics and Lipid Biology, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, U.K.
Biochem Soc Trans. 2018 Feb 19;46(1):119-129. doi: 10.1042/BST20160469. Epub 2018 Jan 12.
Human skin has a distinct profile of fatty acids and related bioactive lipid mediators that regulate many aspects of epidermal and dermal homeostasis, including immune and inflammatory reactions. Sebum lipids act as effective antimicrobial agents, shape immune cell communications and contribute to the epidermal lipidome. The essential fatty acid linoleic acid is crucial for the structure of the epidermal barrier, while polyunsaturated fatty acids act as precursors to eicosanoids, octadecanoids and docosanoids through cyclooxygenase, lipoxygenase and cytochrome P450 monooxygenase-mediated reactions, and endocannabinoids and -acyl ethanolamines. Cross-communication between these families of bioactive lipids suggests that their cutaneous activities should be considered as part of a wider metabolic network that can be targeted to maintain skin health, control inflammation and improve skin pathologies.
人体皮肤具有独特的脂肪酸和相关生物活性脂质介质谱，这些物质调节表皮和真皮的许多方面的稳态，包括免疫和炎症反应。皮脂脂质充当有效的抗菌剂，塑造免疫细胞通讯，并有助于表皮脂质组。必需脂肪酸亚油酸对于表皮屏障的结构至关重要，而多不饱和脂肪酸则通过环加氧酶、脂加氧酶和细胞色素 P450 单加氧酶介导的反应以及内源性大麻素和酰基乙醇胺作为类二十烷酸、十八烷酸和二十二烷酸的前体。这些生物活性脂质家族之间的交叉通讯表明，它们在皮肤中的活性应被视为更广泛代谢网络的一部分，可以针对该网络来维持皮肤健康、控制炎症和改善皮肤病理。
