人类微生物组及特定细菌感染在类风湿关节炎发病机制中的作用
Role of human microbiome and selected bacterial infections in the pathogenesis of rheumatoid arthritis.
作者信息
Roszyk Ewa, Puszczewicz Mariusz
机构信息
Chair and Clinic of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan.
出版信息
Reumatologia. 2017;55(5):242-250. doi: 10.5114/reum.2017.71641. Epub 2017 Oct 28.
Abstract
Microorganisms inhabiting human body form a complex ecosystem. The mutual influence of the microbiome and the immune system of the host constitute the basis for numerous diseases, e.g. pseudomembranous colitis, inflammatory bowel disease, type 1 diabetes, atopic diseases, obesity, reactive arthritis. New molecular diagnostic methods and multi-center studies may help in understanding of the role of microbiota in health and disease. Rheumatoid arthritis has a multi-faceted etiology, and its causes are not entirely understood. There are indications for the influence of microbiomes of oral cavity, intestines, lungs and urinary tract on the development of rheumatoid arthritis. Interactions between microorganisms and human immune system play role in the pathogenesis of the disease.
摘要
寄居于人体的微生物构成了一个复杂的生态系统。微生物群与宿主免疫系统的相互影响是众多疾病的基础，如假膜性结肠炎、炎症性肠病、1型糖尿病、特应性疾病、肥胖症、反应性关节炎。新的分子诊断方法和多中心研究可能有助于理解微生物群在健康和疾病中的作用。类风湿性关节炎病因是多方面的，其病因尚未完全明确。有迹象表明口腔、肠道、肺部和泌尿道的微生物群对类风湿性关节炎的发展有影响。微生物与人类免疫系统之间的相互作用在该疾病的发病机制中起作用。
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