Irie Koichiro, Azuma Tetsuji, Tomofuji Takaaki, Yamamoto Tatsuo
Department of Preventive Dentistry and Dental Public Health, Kanagawa Dental University, Yokosuka 238-8580, Japan.
Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho 501-0296, Japan.
Dent J (Basel). 2023 Aug 12;11(8):194. doi: 10.3390/dj11080194.
Oral microbiota play a pivotal role in maintaining homeostasis, safeguarding the oral cavity, and preventing the onset of disease. Oral dysbiosis has the potential to trigger pro-inflammatory effects and immune dysregulation, which can have a negative impact on systemic health. It is regarded as a key etiological factor for periodontitis. The emergence and persistence of oral dysbiosis have been demonstrated to mediate inflammatory pathology locally and at distant sites. The heightened inflammation observed in oral dysbiosis is dependent upon the secretion of interleukin-17A (IL-17A) by various innate and adaptive immune cells. IL-17A has been found to play a significant role in host defense mechanisms by inducing antibacterial peptides, recruiting neutrophils, and promoting local inflammation via cytokines and chemokines. This review seeks to present the current knowledge on oral dysbiosis and its prevention, as well as the underlying role of IL-17A in periodontitis induced by oral dysbiosis and its impact on systemic inflammatory disease.
口腔微生物群在维持体内平衡、保护口腔以及预防疾病发生方面发挥着关键作用。口腔生态失调有可能引发促炎效应和免疫失调，进而对全身健康产生负面影响。它被视为牙周炎的关键病因。口腔生态失调的出现和持续存在已被证明会在局部和远处介导炎症病理过程。在口腔生态失调中观察到的炎症加剧依赖于各种固有免疫细胞和适应性免疫细胞分泌白细胞介素-17A（IL-17A）。已发现IL-17A通过诱导抗菌肽、招募中性粒细胞以及通过细胞因子和趋化因子促进局部炎症，在宿主防御机制中发挥重要作用。本综述旨在介绍关于口腔生态失调及其预防的当前知识，以及IL-17A在口腔生态失调诱发的牙周炎中的潜在作用及其对全身炎症性疾病的影响。
