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五种氟喹诺酮类药物对分枝杆菌的体外活性比较

Comparative in-vitro activity of five fluoroquinolones against mycobacteria.

作者信息

Davies S, Sparham P D, Spencer R C

出版信息

J Antimicrob Chemother. 1987 May;19(5):605-9. doi: 10.1093/jac/19.5.605.

DOI:10.1093/jac/19.5.605
PMID:3112094
Abstract

Fifty distinct strains of mycobacteria were investigated to determine their in-vitro susceptibility to five new fluoroquinolones (norfloxacin, pefloxacin, ofloxacin, enoxacin and ciprofloxacin). Ofloxacin and ciprofloxacin were found to be the most active, with minimum inhibitory concentrations (MIC) of 1.25 mg/l or less to all strains of Mycobacterium tuberculosis, M. bovis, M. xenopi, M. kansasii and BCG tested. All agents showed little activity against M. malmoense and M. avium-intracellulare complex with MIC values of greater than 2.5 mg/l.

摘要

对50种不同的分枝杆菌菌株进行了研究，以确定它们对5种新型氟喹诺酮类药物（诺氟沙星、培氟沙星、氧氟沙星、依诺沙星和环丙沙星）的体外敏感性。结果发现，氧氟沙星和环丙沙星活性最强，对所有测试的结核分枝杆菌、牛分枝杆菌、偶发分枝杆菌、堪萨斯分枝杆菌和卡介苗菌株的最低抑菌浓度（MIC）为1.25mg/l或更低。所有药物对马尔默分枝杆菌和鸟分枝杆菌-胞内分枝杆菌复合体的活性均较弱，MIC值大于2.5mg/l。

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