Zhu Tang, Wu Junrong, Zhao Ning, Cai Chao, Qian Zhenchao, Si Fangfang, Luo Heng, Guo Jing, Lai Xuan, Shao Longquan, Xu Jian
Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
School of Chemical Science, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Adv Healthc Mater. 2018 Apr;7(7):e1701086. doi: 10.1002/adhm.201701086. Epub 2018 Jan 15.
Hemostatic fabrics are most commonly used in baseline emergency treatment; however, the unnecessary blood loss due to the excessive blood absorption by traditional superhydrophilic fabrics is overlooked. Herein, for the first time, superhydrophobic/superhydrophilic Janus fabrics (superhydrophobic on one side and superhydrophilic on the other) are proposed: the superhydrophilic part absorbs water in the blood to expedite the clotting while the superhydrophobic part prevents blood from further permeating. Compared with the common counterparts, effective bleeding control with reducing blood loss more than 50% can be achieved while the breathability largely remain by using Janus fabrics. The proposed prototypes can even prolong the survival time in the rat model with serious bleeding. This strategy for reducing blood loss via simply tuning wettability is promising for the practical applications.
止血织物最常用于基础急救治疗；然而，传统超亲水性织物因过度吸收血液导致的不必要失血却被忽视了。在此，首次提出了超疏水/超亲水双面织物（一面超疏水，另一面超亲水）：超亲水部分吸收血液中的水分以加速凝血，而超疏水部分防止血液进一步渗透。与普通同类产品相比，使用双面织物可有效控制出血，减少超过50%的失血量，同时透气性基本保持不变。所提出的原型甚至可以延长严重出血大鼠模型的存活时间。这种通过简单调节润湿性来减少失血的策略在实际应用中很有前景。
