Veloso Aparecida Gabriela Bexiga, Lima Nathalia Edviges Alves, de Marco Ornelas Elisabete, Cardoso Clever Gomes, Marques Mara Rubia, da Costa Aguiar Alves Reis Beatriz, Fonseca Fernando Luiz Affonso, Maifrino Laura Beatriz Mesiano
Laboratório de Estudos Morfoquantitativo e Imunohistoquímico da USJT, R. Taquari, 546, São Paulo, SP, CEP 03166-000, Brazil.
Universidade Federal de Goiás, Avenida Esperança s/n, Goiânia, GO, CEP 74690-900, Brazil.
Med Mol Morphol. 2018 Jun;51(2):118-127. doi: 10.1007/s00795-018-0179-x. Epub 2018 Jan 15.
Menopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized LDL-R knockout; sedentary ovariectomized LDL-R knockout; and trained ovariectomized LDL-R knockout. Physical exercise practice promoted improvement in biometric and biochemical parameters analyzed, with reduction of visceral adipose tissue and VLDL, triglycerides, total cholesterol, and blood glucose levels. In addition, physical exercise practice altered the morphology of pancreatic islets and improved their response to the effects of menopause. Thus, physical exercise practice was fundamental to minimize the effects of dyslipidemia associated with ovariectomy in the pancreatic tissue of LDL-R knockout animals, contributing to reduce the risk of developing cardiac diseases in the menopause period.
更年期女性患心脏病的风险很高。然而，体育锻炼可以扭转这种情况。我们评估了适度有氧体育锻炼对通过卵巢切除术剥夺雌激素的低密度脂蛋白受体基因敲除小鼠胰腺的生化、形态和生理影响。将动物分为六组（n = 5）：久坐不动的未卵巢切除对照；久坐不动的卵巢切除对照；训练有素的卵巢切除对照；久坐不动的未卵巢切除低密度脂蛋白受体基因敲除；久坐不动的卵巢切除低密度脂蛋白受体基因敲除；以及训练有素的卵巢切除低密度脂蛋白受体基因敲除。体育锻炼促进了所分析的生物特征和生化参数的改善，减少了内脏脂肪组织以及极低密度脂蛋白、甘油三酯、总胆固醇和血糖水平。此外，体育锻炼改变了胰岛的形态，并改善了它们对更年期影响的反应。因此，体育锻炼对于将低密度脂蛋白受体基因敲除动物胰腺组织中与卵巢切除术相关的血脂异常影响降至最低至关重要，有助于降低更年期患心脏病的风险。
