Molu Jean-Patrick, Essome Marie Chantal Ngonde, Monamele Chavely Gwladys, Njouom Richard
Laboratoire de Biologie Humaine, Centre de Recherches Médicales, Institut de Recherches Médicales et d'Etudes de Plantes Médicinales, PO Box 13033, Yaounde, Cameroon.
Yaounde University Teaching Hospital, PO Box 1634, Yaounde, Cameroon.
BMC Res Notes. 2018 Jan 16;11(1):39. doi: 10.1186/s13104-018-3159-2.
This study was performed in order to fill the gap of knowledge regarding sero-epidemiology of hepatitis B virus (HBV) amongst Human Immunodeficiency virus (HIV)-infected patients and to assess the risk factors associated with HBV co-infection in a rural locality of Cameroon. A retrospective and cross-sectional study was carried out from January 2008 to April 2014 within the Mfou District Hospital. Naive HIV-infected patients were enrolled in the study and tested for hepatitis B surface antigen (HBsAg). Preliminary pre-therapeutic data essential for follow-up was collected from the participants.
Overall, the sample size was constituted of 712 HIV-infected patients. The prevalence of HBsAg was 8.99%. A significant difference was observed in the proportion of HBsAg positive subjects with respect to the year of inclusion; higher proportions were observed between 2011 and 2014 (P-value = 0.007). Majority of HBV co-infected participants had severe immuno-suppression with CD4 counts lower than 100 cells/µL as compared to HIV mono-infected population but the difference was not statistically significant. Our results confirm the high prevalence for HBV infection among HIV-infected patients in the Mfou District Hospital. These findings will enable stake holders to be better armed in the elimination of viral hepatitis as a public health problem.
开展本研究是为了填补喀麦隆一个农村地区人类免疫缺陷病毒（HIV）感染患者中乙型肝炎病毒（HBV）血清流行病学知识的空白，并评估与HBV合并感染相关的危险因素。2008年1月至2014年4月期间在姆福区医院开展了一项回顾性横断面研究。纳入未接受过治疗的HIV感染患者并对其进行乙型肝炎表面抗原（HBsAg）检测。从参与者那里收集了随访所需的初步治疗前数据。
总体而言，样本量由712名HIV感染患者组成。HBsAg的患病率为8.99%。观察到HBsAg阳性受试者的比例在纳入年份方面存在显著差异；2011年至2014年期间观察到的比例更高（P值=0.007）。与HIV单一感染人群相比，大多数HBV合并感染的参与者存在严重免疫抑制，CD4细胞计数低于100个/微升，但差异无统计学意义。我们的结果证实了姆福区医院HIV感染患者中HBV感染的高患病率。这些发现将使利益相关者在消除作为公共卫生问题的病毒性肝炎方面有更充分的准备。
