Kumar Mayur, Curtis Anthony, Hoskins Clare
School of Pharmacy, Institute of Science and Technology for Medicine, Keele University, Keele, Staffordshire ST5 6DB, UK.
Pharmaceutics. 2018 Jan 14;10(1):11. doi: 10.3390/pharmaceutics10010011.
Anti-microbial resistance is a growing problem that has impacted the world and brought about the beginning of the end for the old generation of antibiotics. Increasingly, more antibiotics are being prescribed unnecessarily and this reckless practice has resulted in increased resistance towards these drugs, rendering them useless against infection. Nanotechnology presents a potential answer to anti-microbial resistance, which could stimulate innovation and create a new generation of antibiotic treatments for future medicines. Preserving existing antibiotic activity through novel formulation into or onto nanotechnologies can increase clinical longevity of action against infection. Additionally, the unique physiochemical properties of nanoparticles can provide new anti-bacterial modes of action which can also be explored. Simply concentrating on antibiotic prescribing habits will not resolve the issue but rather mitigate it. Thus, new scientific approaches through the development of novel antibiotics and formulations is required in order to employ a new generation of therapies to combat anti-microbial resistance.
抗菌耐药性是一个日益严重的问题，它已经影响到全球，并导致了新一代抗生素的出现。越来越多的抗生素被不必要地开出处方，这种鲁莽的做法导致了对这些药物的耐药性增加，使其对感染无效。纳米技术为抗菌耐药性提供了一个潜在的解决方案，它可以刺激创新，并为未来的药物创造新一代的抗生素治疗方法。通过将现有抗生素制成纳米技术制剂或涂覆在纳米技术上，保留其活性，可以提高其对感染的临床作用寿命。此外，纳米颗粒独特的物理化学性质可以提供新的抗菌作用模式，这也值得探索。仅仅关注抗生素的处方习惯并不能解决这个问题，而只能缓解它。因此，需要通过开发新型抗生素和制剂来采用新的科学方法，以便采用新一代疗法来对抗抗菌耐药性。
