Laboratoire MIVEGEC (UMR CNRS 5290, UR IRD 224, UM), Montpellier, France.
Faculté de Philosophie, Université Laval, Québec, Canada.
PLoS Biol. 2018 Jan 18;16(1):e2003815. doi: 10.1371/journal.pbio.2003815. eCollection 2018 Jan.
The continual emergence of new pathogens and the increased spread of antibiotic resistance in bacterial populations remind us that microbes are living entities that evolve at rates that impact public health interventions. Following the historical thread of the works of Pasteur and Darwin shows how reconciling clinical microbiology, ecology, and evolution can be instrumental to understanding pathology, developing new therapies, and prolonging the efficiency of existing ones.
新病原体的不断出现和细菌种群中抗生素耐药性的增加提醒我们,微生物是具有进化能力的生物体,其进化速度会对公共卫生干预措施产生影响。循着巴斯德和达尔文的著作的历史脉络可以看出,如何协调临床微生物学、生态学和进化生物学,对于理解病理学、开发新疗法和延长现有疗法的效率至关重要。