Biomedical Research Center, Northwest Minzu University, Lanzhou, 730030, P. R. China.
Department of Microbiology, Government College University Faisalabad, Faisalabad, Pakistan.
Antimicrob Resist Infect Control. 2020 Aug 10;9(1):131. doi: 10.1186/s13756-020-00795-6.
Antibiotic exposure leads to massive selective pressures that initiate the emergence and spread of antibiotic resistance in commensal and pathogenic bacteria. The slow process of developing new antibiotics makes this approach counterintuitive for combatting the rapid emergence of new antibiotic resistant pathogens. Therefore, alternative approaches such as, the development of nucleic acid-based anti-bacterial treatments, anti-bacterial peptides, bacteriocins, anti-virulence compounds and bacteriophage therapies should be exploited to cope infections caused by resistant superbugs. In this editorial, we discuss how the newly popular CRISPR-Cas system has been applied to combat antibiotic resistance.
抗生素暴露会导致巨大的选择性压力，从而引发共生菌和病原菌中抗生素耐药性的出现和传播。开发新抗生素的缓慢过程使得这种方法在对抗新出现的抗生素耐药性病原体方面具有反直觉性。因此，应该利用基于核酸的抗菌治疗、抗菌肽、细菌素、抗毒化合物和噬菌体疗法等替代方法来应对耐药超级细菌引起的感染。在这篇社论中，我们讨论了新流行的 CRISPR-Cas 系统如何被应用于对抗抗生素耐药性。
