补体3b/补体3bi沉积不足及酵母调理作用缺陷。I. 缺乏关键辅助因子活性的证据。
Suboptimal C3b/C3bi deposition and defective yeast opsonization. I. Evidence for the absence of essential co-factor activity.
作者信息
Turner M W, Seymour N D, Kazatchkine M D, Mowbray J F
出版信息
Clin Exp Immunol. 1985 Nov;62(2):427-34.
Abstract
Defective yeast opsonization in sera with no demonstrable abnormality of known complement components is associated with the absence of inactivity of a co-factor which enhances the deposition of C3 fragments (C3b/C3bi) derived from both classical and alternative pathways of complement activation. The factor binds strongly to zymosan at 4 degrees C and loses its biological activity completely when heated for 30 min at 56 degrees C but not when similarly heated at 50 degrees C. Sera with defective deposition of C3 fragments may be readily corrected with small quantities of sera having normal function. Sera with the defect do not correct other similar sera.
摘要
在已知补体成分无明显异常的血清中，酵母调理作用缺陷与一种辅助因子的失活有关，该辅助因子可增强源自补体激活经典途径和替代途径的C3片段（C3b/C3bi）的沉积。该因子在4℃时与酵母聚糖强烈结合，在56℃加热30分钟会完全丧失其生物活性，但在50℃进行类似加热时则不会。C3片段沉积有缺陷的血清可通过加入少量功能正常的血清轻易得到纠正。有缺陷的血清不能纠正其他类似血清。
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