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青石斑鱼中干扰素刺激基因15在抗青石斑鱼虹彩病毒（RSIV）攻击时的表达分析

Expression Analysis of Interferon-Stimulated Gene 15 in the Rock Bream against Rock Bream Iridovirus (RSIV) Challenge.

作者信息

Kim Kyung-Hee, Yang In Jung, Kim Woo-Jin, Park Choul-Ji, Park Jong-Won, Noh Gyeong Eon, Lee Seunghyung, Lee Young Mee, Hwang Hyung Kyu, Kim Hyun Chul

机构信息

Genetics and Breeding Research Center, National Institute of Fisheries Science (NIFS), Geoje 53334, Republic of Korea.

出版信息

Dev Reprod. 2017 Dec;21(4):371-378. doi: 10.12717/DR.2017.21.4.371. Epub 2017 Dec 31.

DOI:10.12717/DR.2017.21.4.371
PMID:29354783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5769131/
Abstract

Interferon-stimulated gene 15 (ISG15) is known to interfere with viral replication and infection by limiting the viral infection of cells. Interferon-stimulated gene 15 (ISG15) interferes with viral replication and infectivity by limiting viral infection in cells. It also plays an important role in the immune response. In this study, tissue-specific expression of ISG15 in healthy rock bream samples and spatial and temporal expression analysis of rock bream ISG15 (RbISG15) were performed following rock bream iridovirus (RSIV) infection. RbISG15 expression was significantly higher in the eye, gill, intestine, kidney, liver, muscle, spleen, and stomach, but low in the brain. There were particularly high levels of expression in the liver and muscle. RbISG15 expression was also examined in several tissues and at various times following RSIV infection. ISG15 expression increased within 3 h in the whole body and decreased at 24 h after infection. In addition, temporal expression of several tissues following RSIV infection showed a similar pattern in the muscle, kidney, and spleen, increasing at 3 h and decreasing at 72 h. These results suggest that ISG15 plays an important role in the immune response of rock bream. Overall, this study characterizes the response of RbISG15 following RSIV infection.

摘要

干扰素刺激基因15（ISG15）已知可通过限制病毒对细胞的感染来干扰病毒复制和感染。干扰素刺激基因15（ISG15）通过限制细胞中的病毒感染来干扰病毒复制和感染性。它在免疫反应中也起着重要作用。在本研究中，对健康真鲷样本中ISG15的组织特异性表达以及真鲷虹彩病毒（RSIV）感染后真鲷ISG15（RbISG15）的时空表达进行了分析。RbISG15在眼、鳃、肠、肾、肝、肌肉、脾和胃中的表达显著较高，但在脑中较低。在肝和肌肉中表达水平尤其高。还在RSIV感染后的几个组织和不同时间点检测了RbISG15的表达。感染后3小时内全身ISG15表达增加，24小时后下降。此外，RSIV感染后几个组织的时间表达在肌肉、肾和脾中显示出相似的模式，在3小时时增加，在72小时时下降。这些结果表明ISG15在真鲷的免疫反应中起重要作用。总体而言，本研究描述了RSIV感染后RbISG15的反应特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2d4/5769131/7a6095cd0152/dr-21-4-371-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2d4/5769131/7a6095cd0152/dr-21-4-371-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2d4/5769131/76673db6eba9/dr-21-4-371-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2d4/5769131/7a6095cd0152/dr-21-4-371-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2d4/5769131/7a6095cd0152/dr-21-4-371-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2d4/5769131/76673db6eba9/dr-21-4-371-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2d4/5769131/7a6095cd0152/dr-21-4-371-g1.jpg

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