González-Cabezas C, Fernández C E
1 Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
2 College of Dental Medicine-Illinois, Midwestern University, Downers Grove, IL, USA.
Adv Dent Res. 2018 Feb;29(1):55-59. doi: 10.1177/0022034517740124.
Remineralization of caries lesions is naturally achieved by salivary ions, and it can be enhanced by external factors or elements such as fluoride. Numerous studies have demonstrated the remineralizing efficacy of fluoride therapies as well as the limitations with some groups of the population. Consequently, developing new remineralization therapies to close this gap in efficacy has been a priority for the last 2 decades. In this review, we summarize and briefly discuss some of the latest advances in remineralization therapies. Most new therapies try to enhance the effect of fluoride by adding other potentially active ingredients to the formulation, such as calcium, phosphate, stannous, xylitol, and arginine. Other remineralization strategies have focused on creating remineralizing scaffolds within the lesions (e.g., self-assembling peptides). While several of the new remineralization strategies have progressed significantly in recent years, for most of them, the evidence is still insufficient to assess their true clinical potential.
龋损的再矿化自然是通过唾液离子实现的，并且它可以通过诸如氟化物等外部因素或元素得到增强。大量研究已经证明了氟化物疗法的再矿化功效以及对某些人群的局限性。因此，在过去20年里，开发新的再矿化疗法以弥补疗效上的这一差距一直是优先事项。在本综述中，我们总结并简要讨论再矿化疗法的一些最新进展。大多数新疗法试图通过在配方中添加其他潜在活性成分（如钙、磷酸盐、亚锡、木糖醇和精氨酸）来增强氟化物的效果。其他再矿化策略则专注于在龋损内创建再矿化支架（例如自组装肽）。虽然近年来几种新的再矿化策略取得了显著进展，但对于其中大多数而言，证据仍然不足以评估其真正的临床潜力。
