Kim Jungyoon, Lee Suji L, Kang Ilhyang, Song Youme A, Ma Jiyoung, Hong Young Sun, Park Shinwon, Moon Seog In, Kim Soojeong, Jeong Semi, Kim Jieun E
1 Ewha Brain Institute, Ewha Womans University , Seoul, South Korea .
2 Department of Brain and Cognitive Sciences, Division of Convergence, Scranton College, Ewha Womans University , Seoul, South Korea .
J Med Food. 2018 May;21(5):433-444. doi: 10.1089/jmf.2017.4064. Epub 2018 Jan 22.
Insufficient sleep, insomnia, and sleep-related problems are important health issues, as their overall prevalence accounts for about 30% of the general population. The aim of this study was to systematically review previous studies investigating the effects of orally administered single plant-derived extracts on sleep-related outcomes in humans. Data sources were PubMed, Google Scholar, and Cochrane Library. The data search was conducted in two steps: step 1, names of plants which have been studied as sleep aids in humans were searched and retrieved; and step 2, each ingredient listed in step 1 was then added into the search term. Only original articles or reviews were applicable to the scope of this review. Studies on human subjects, with or without sleep-related disorders, were included. Sleep-related disorders refer to not only insomnia or sleep behavior disorders but also diseases with sleep-related symptoms. Studies were considered eligible for this review when the plant extracts were administered orally. Outcome measures relevant to sleep quality, duration, or other sleep-related problems were included. Twenty-one plants were listed in the first step of the search as potential candidates for natural sleep aids. Seventy-nine articles using these single plant-derived natural products were included in the final review. Although valerian was most frequently studied, conflicting results were reported, possibly due to the various outcome measures of each study. Other plants were not as rigorously tested in human studies. There was limited evidence with inconclusive results regarding the effects of single plant-derived natural products on sleep, warranting further studies.
睡眠不足、失眠及与睡眠相关的问题是重要的健康问题，因为它们在普通人群中的总体患病率约为30%。本研究的目的是系统回顾以往关于口服单一植物提取物对人类睡眠相关结果影响的研究。数据来源为PubMed、谷歌学术和考克兰图书馆。数据检索分两步进行：第一步，检索并获取已被研究作为人类睡眠辅助剂的植物名称；第二步，将第一步列出的每种成分添加到检索词中。仅原创文章或综述适用于本综述范围。纳入了对有或无睡眠相关障碍的人类受试者的研究。睡眠相关障碍不仅指失眠或睡眠行为障碍，还包括有睡眠相关症状的疾病。当植物提取物经口服给药时，这些研究被认为符合本综述的条件。纳入了与睡眠质量、时长或其他与睡眠相关问题相关的结局指标。在检索的第一步中列出了21种植物作为天然睡眠辅助剂的潜在候选者。最终综述纳入了79篇使用这些单一植物来源天然产物的文章。尽管缬草是研究最频繁的，但报道的结果相互矛盾，这可能是由于每项研究的结局指标各不相同。其他植物在人体研究中的测试不够严格。关于单一植物来源天然产物对睡眠影响的证据有限且结果尚无定论，因此需要进一步研究。
