School of Behavioural and Health Sciences, Australian Catholic University, Banyo QLD 4014, Australia.
High Performance Unit, Swimming Australia, Brisbane QLD 4519, Australia.
Nutrients. 2020 Aug 25;12(9):2579. doi: 10.3390/nu12092579.
Disturbed sleep may negatively influence physical health, cognitive performance, metabolism, and general wellbeing. Nutritional interventions represent a potential non-pharmacological means to increase sleep quality and quantity.
(1) Identify an optimal suite of nutritional ingredients and (2) validate the effects of this suite utilising polysomnography, and cognitive and balance tests.
The optimal and least optimal combinations of six ingredients were identified utilising 55 male participants and a Box-Behnken predictive model. To validate the model, 18 healthy, male, normal sleepers underwent three trials in a randomised, counterbalanced design: (1) optimal drink, (2) least optimal drink, or (3) placebo were provided before bed in a double-blinded manner. Polysomnography was utilised to measure sleep architecture. Cognitive performance, postural sway, and subjective sleep quality, were assessed 30 min after waking.
The optimal drink resulted in a significantly shorter sleep onset latency (9.9 ± 12.3 min) when compared to both the least optimal drink (26.1 ± 37.4 min) and the placebo drink (19.6 ± 32.0 min). No other measures of sleep, cognitive performance, postural sway, and subjective sleep quality were different between trials.
A combination of ingredients, optimised to enhance sleep, significantly reduced sleep onset latency. No detrimental effects on sleep architecture, subjective sleep quality or next day performance were observed.
睡眠紊乱可能会对身体健康、认知表现、新陈代谢和整体健康产生负面影响。营养干预是一种提高睡眠质量和数量的潜在非药物手段。
（1）确定最佳的营养成分组合，（2）利用多导睡眠图以及认知和平衡测试来验证该组合的效果。
使用 55 名男性参与者和 Box-Behnken 预测模型确定了六种成分的最佳和最差组合。为了验证该模型，18 名健康的男性正常睡眠者在随机、对照设计的 3 次试验中接受了以下处理：（1）在睡前以双盲方式提供最佳饮料，（2）提供最差饮料，（3）提供安慰剂。利用多导睡眠图测量睡眠结构。在醒来后 30 分钟评估认知表现、姿势摇摆和主观睡眠质量。
与最差饮料（26.1 ± 37.4 min）和安慰剂饮料（19.6 ± 32.0 min）相比，最佳饮料可显著缩短睡眠潜伏期（9.9 ± 12.3 min）。在其他睡眠、认知表现、姿势摇摆和主观睡眠质量的测量中，各试验之间没有差异。
优化组合的成分可显著缩短睡眠潜伏期，增强睡眠。没有观察到对睡眠结构、主观睡眠质量或次日表现的不利影响。
