Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Eur J Epidemiol. 2018 Aug;33(8):741-750. doi: 10.1007/s10654-018-0355-2. Epub 2018 Jan 22.
Modeling variation at population level has become increasingly valued, but no clear application exists for modeling differential variation in health between individuals within a given population. We applied Goldstein's method (in: Everrit, Howell (eds) Encyclopedia of statistics in behavioral science, Wiley, Hoboken, 2005) to model individual heterogeneity in body mass index (BMI) as a function of basic sociodemographic characteristics, each independently and jointly. Our analytic sample consisted of 643,315 non-pregnant women aged 15-49 years pooled from the latest Demographic Health Surveys (rounds V, VI, or VII; years 2005-2014) across 57 low- and middle-income countries. Individual variability in BMI ranged from 9.8 (95% CI: 9.8, 9.9) for the youngest to 23.2 (95% CI: 22.9, 23.5) for the oldest age group; 14.2 (95% CI: 14.1, 14.3) for those with no formal education to 19.7 (95% CI: 19.5, 19.9) for those who have completed higher education; and 13.6 (95% CI: 13.5, 13.7) for the poorest quintile to 20.1 (95% CI: 20.0, 20.2) for the wealthiest quintile group. Moreover, variability in BMI by age was also different for different socioeconomic groups. Empirically testing the fundamental assumption of constant variance and identifying groups with systematically large differentials in health experiences have important implications for reducing health disparity.
在人群水平上进行变异建模已经变得越来越重要,但在给定人群中,个体之间健康差异的变异性建模还没有明确的应用。我们应用 Goldstein 的方法(在:Everrit,Howell(eds)《行为科学统计学百科全书》,Wiley,Hoboken,2005 年)来模拟体重指数(BMI)的个体异质性,作为基本社会人口特征的函数,每个特征独立和共同作用。我们的分析样本由来自 57 个低收入和中等收入国家的最新人口健康调查(第五轮、第六轮或第七轮;2005-2014 年)中 15-49 岁的 643315 名非孕妇组成。BMI 的个体变异性范围从最年轻的 9.8(95%CI:9.8,9.9)到最年长的 23.2(95%CI:22.9,23.5);从没有正规教育的 14.2(95%CI:14.1,14.3)到完成高等教育的 19.7(95%CI:19.5,19.9);从最贫穷的五分位数的 13.6(95%CI:13.5,13.7)到最富有的五分位数的 20.1(95%CI:20.0,20.2)。此外,不同社会经济群体的 BMI 随年龄的变化也不同。经验检验方差不变的基本假设,并确定健康体验存在系统差异的群体,对减少健康差距具有重要意义。