Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
Am J Physiol Renal Physiol. 2018 May 1;314(5):F675-F678. doi: 10.1152/ajprenal.00580.2017. Epub 2017 Dec 20.
Mounting evidence suggests that there is an internal molecular "clock" within the kidney to help maintain normal renal function. Disturbance of the kidney circadian rhythm may pose a threat to water and electrolyte homeostasis and blood pressure regulation, among many other problems. The identification of circadian genes facilitated a more comprehensive appreciation of the importance of "keeping the body on time"; however, our knowledge is very limited with regard to how circadian genes regulate kidney function. In this brief review, we summarize recent progress in circadian control of renal physiology, with a particular focus on aryl hydrocarbon receptor nuclear translocator-like protein (Arntl1; also called Bmal1).
越来越多的证据表明，肾脏内部存在一种内在的分子“时钟”，有助于维持正常的肾功能。肾脏昼夜节律的紊乱可能对水和电解质平衡以及血压调节等诸多问题构成威胁。昼夜节律基因的鉴定使人们更全面地认识到“保持身体的时间同步性”的重要性；然而，我们对于昼夜节律基因如何调节肾脏功能的了解还非常有限。在这篇简要的综述中，我们总结了肾脏生理学昼夜节律控制的最新进展，特别关注芳香烃受体核转位蛋白样蛋白 (Arntl1；也称为 Bmal1)。
