von Drygalski Annette, Rappazzo Katherine C, Barnes Richard F W, Chang Eric Y
Division of Hematology/Oncology, Department of Medicine, University of California San Diego, San Diego, CA, USA.
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Arthritis. 2017;2017:1578623. doi: 10.1155/2017/1578623. Epub 2017 Dec 5.
Hemophilic arthropathy is a progressive, disabling condition with poorly understood pathobiology. Since there is an emerging interest to study the role of intra-articular fat pad size and biology in arthritic conditions, we explored fat pad volume changes in hemophilic arthropathy and to what extent they differed from osteoarthritis. We matched a cohort of 13 adult patients with hemophilic arthropathy of the knee with age- and gender-matched cohorts without osteoarthritis ("control cohort") and with the same degree of radiographic osteoarthritis ("OA cohort") in 1 : 2 fashion. Infrapatellar fat pad (IPFP) and suprapatellar fat pad (SPFP) volumes were calculated based on magnetic resonance imaging and differences in fat pad volumes, demographics, height, weight, and osteoarthritis scores were evaluated. Fat pad volumes were positively associated with body size parameters in all three cohorts but were unaffected by the degree of osteoarthritis. While IPFP volumes did not differ between cohorts, SPFP volumes expanded disproportionally with weight in hemophilia patients. Our observations indicate that IPFPs and SPFPs behave biologically differently in response to different arthritic stimuli. The exaggerated expansion of the SPFP in hemophilia patients highlights the importance of further studying the implications of fat pad biology for progression of hemophilic arthropathy.
血友病性关节病是一种进行性致残疾病，其病理生物学机制尚不清楚。鉴于目前对研究关节内脂肪垫大小和生物学特性在关节炎疾病中的作用的兴趣日益浓厚，我们探讨了血友病性关节病中脂肪垫体积的变化，以及它们与骨关节炎的差异程度。我们将13例成年膝关节血友病性关节病患者与年龄和性别匹配的无骨关节炎队列（“对照队列”）以及具有相同程度影像学骨关节炎的队列（“骨关节炎队列”）以1∶2的比例进行匹配。基于磁共振成像计算髌下脂肪垫（IPFP）和髌上脂肪垫（SPFP）的体积，并评估脂肪垫体积、人口统计学特征、身高、体重和骨关节炎评分的差异。在所有三个队列中，脂肪垫体积均与身体大小参数呈正相关，但不受骨关节炎程度的影响。虽然各队列之间IPFP体积没有差异，但血友病患者的SPFP体积随体重不成比例地增大。我们的观察结果表明，IPFP和SPFP在对不同关节炎刺激的生物学反应上存在差异。血友病患者SPFP的过度增大凸显了进一步研究脂肪垫生物学特性对血友病性关节病进展影响的重要性。
