乌干达儿童感染卡波氏肉瘤相关疱疹病毒的年龄和随后的抗体值。
Age of Infection with Kaposi Sarcoma-Associated Herpesvirus and Subsequent Antibody Values Among Children in Uganda.
机构信息
From the Clinical Research Department, Faculty of Infectious and Tropical Diseases, MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
London School of Hygiene and Tropical Medicine, London, United Kingdom.
出版信息
Pediatr Infect Dis J. 2018 Aug;37(8):e225-e228. doi: 10.1097/INF.0000000000001909.
Abstract
We investigated associations between Kaposi sarcoma-associated herpesvirus (KSHV) seroconversion age and KSHV antibody values in Ugandan children. Every annual delay in KSHV seroconversion age was associated with a reduction of 19% (P < 0.0001) in K8.1 and 27% (P < 0.0001) in ORF73 antibody values at 6 years of age. Early infection may be an important risk factor for KSHV pathogenesis and viral shedding in saliva, leading to transmission.
摘要
我们研究了卡波济肉瘤相关疱疹病毒（KSHV）血清转化年龄与乌干达儿童 KSHV 抗体值之间的关系。KSHV 血清转化年龄每延迟一年，6 岁时 K8.1 抗体值降低 19%（P<0.0001），ORF73 抗体值降低 27%（P<0.0001）。早期感染可能是 KSHV 发病机制和唾液中病毒脱落导致传播的一个重要危险因素。
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2
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